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Drug Interactions between calcium carbonate / famotidine / magnesium hydroxide and Vyvanse

This report displays the potential drug interactions for the following 2 drugs:

  • calcium carbonate/famotidine/magnesium hydroxide
  • Vyvanse (lisdexamfetamine)

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Interactions between your drugs

Moderate

famotidine lisdexamfetamine

Applies to: calcium carbonate / famotidine / magnesium hydroxide and Vyvanse (lisdexamfetamine)

Consumer information for this interaction is not currently available.

MONITOR: Famotidine may cause QTc prolongation. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. According to the manufacturer, prolongation of the QT interval has been reported very rarely in patients with impaired renal function whose dose/dosing interval of famotidine may not have been adjusted appropriately. In general, the risk of an individual agent or a combination of these agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).

MANAGEMENT: Caution and clinical monitoring are recommended if famotidine is used in combination with other drugs that can prolong the QT interval. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.

References

  1. "Product Information. Pepcid (famotidine)." Merck & Co, Inc, West Point, PA.
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Moderate

calcium carbonate lisdexamfetamine

Applies to: calcium carbonate / famotidine / magnesium hydroxide and Vyvanse (lisdexamfetamine)

Ask your doctor before using calcium carbonate together with lisdexamfetamine. Using these medications together can increase the absorption of lisdexamfetamine and may increase its effects. This can cause restlessness, tremor, rapid breathing, confusion, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

magnesium hydroxide lisdexamfetamine

Applies to: calcium carbonate / famotidine / magnesium hydroxide and Vyvanse (lisdexamfetamine)

Ask your doctor before using magnesium hydroxide together with lisdexamfetamine. Using these medications together can increase the absorption of lisdexamfetamine and may increase its effects. This can cause restlessness, tremor, rapid breathing, confusion, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Minor

famotidine calcium carbonate

Applies to: calcium carbonate / famotidine / magnesium hydroxide and calcium carbonate / famotidine / magnesium hydroxide

Information for this minor interaction is only available at a professional reading level.

For clinical details see professional interaction data.

Minor

famotidine magnesium hydroxide

Applies to: calcium carbonate / famotidine / magnesium hydroxide and calcium carbonate / famotidine / magnesium hydroxide

Information for this minor interaction is only available at a professional reading level.

For clinical details see professional interaction data.

Drug and food interactions

Moderate

calcium carbonate food

Applies to: calcium carbonate / famotidine / magnesium hydroxide

Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

lisdexamfetamine food

Applies to: Vyvanse (lisdexamfetamine)

Using lisdexamfetamine together with alcohol can increase the risk of cardiovascular side effects such as increased heart rate, chest pain, or blood pressure changes. You should avoid or limit the use of alcohol while being treated with lisdexamfetamine. Let your doctor know if you experience severe or frequent headaches, chest pain, and/or a fast or pounding heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.