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Drug Interactions between cabotegravir / rilpivirine and nirmatrelvir / ritonavir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

ritonavir cabotegravir

Applies to: nirmatrelvir / ritonavir and cabotegravir / rilpivirine

Consumer information for this interaction is not currently available.

CONTRAINDICATED: Coadministration with inducers of uridine diphosphate glucuronosyltransferase (UGT)1A1 or 1A9 may decrease the plasma concentrations of cabotegravir. Cabotegravir is primarily metabolized by UGT1A1 and to a lesser extent by UGT 1A9. In 15 study subjects given a single 30 mg dose of cabotegravir with the UGT 1A1 inducer rifampin (600 mg once daily), mean cabotegravir peak plasma concentration (Cmax) and systemic exposure (AUC) were reduced by 6% and 59%, respectively. Loss of therapeutic efficacy of cabotegravir may occur.

MANAGEMENT: According to the manufacturer of cabotegravir, due to the potential for loss of therapeutic efficacy, its concomitant use with UGT 1A1 inducers including, but not limited to carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifampin, and rifapentine is considered contraindicated.

Drug and food interactions

Moderate

ritonavir food

Applies to: nirmatrelvir / ritonavir

Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.

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Moderate

rilpivirine food

Applies to: cabotegravir / rilpivirine

Food significantly increases the absorption of rilpivirine. You should take each dose of rilpivirine with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Grapefruit juice can also increase the absorption of rilpivirine and should preferably be avoided.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.