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Drug Interactions between brincidofovir and Entresto

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

sacubitril brincidofovir

Applies to: Entresto (sacubitril / valsartan) and brincidofovir

Sacubitril may increase the blood levels and side effects of brincidofovir. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. If you do need to take both medications, you may lessen the risk and severity of interaction by taking sacubitril at least 3 hours after brincidofovir. You may also require more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as diarrhea, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

valsartan food

Applies to: Entresto (sacubitril / valsartan)

If you are taking valsartan you should avoid potassium-containing salt substitutes or over-the-counter potassium supplements without first talking to your doctor. This can cause high levels of potassium in your blood. High levels of potassium can cause weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Call your doctor at once if you have any of these symptoms.

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Moderate

brincidofovir food

Applies to: brincidofovir

Food may decrease the blood levels of brincidofovir. It is recommended that you take brincidofovir on an empty stomach, meaning no food should be eaten for at least two hours before or after taking brincidofovir. If necessary, you may take the oral tablets (but not the suspension formulation) with a low-fat meal. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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