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Drug Interactions between Braftovi and Ingrezza

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

valbenazine encorafenib

Applies to: Ingrezza (valbenazine) and Braftovi (encorafenib)

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration of valbenazine with strong CYP450 3A4 inducers may decrease the plasma concentrations and therapeutic effects of valbenazine and its active metabolite, which are substrates of the isoenzyme. The proposed mechanism is induction of CYP450 3A4-mediated metabolism of valbenazine.

MANAGEMENT: The use of valbenazine with strong CYP450 3A4 inducers should generally be avoided. If concomitant use is required, caution and close clinical and laboratory monitoring are recommended. Dosage adjustments may be required whenever a strong CYP450 3A4 inducer is added to or withdrawn from therapy. Alternative treatment may be considered if an interaction is suspected.

Drug and food interactions

Major

valbenazine food

Applies to: Ingrezza (valbenazine)

Grapefruit and grapefruit juice may increase the blood levels and effects of valbenazine, such as drowsiness and an irregular heart rhythm problem called QT prolongation. Irregular heart rhythm problems may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have questions or concerns. Do not add grapefruit products to your diet, or increase or decrease the amount currently in your diet without first talking to your doctor. You may need a dose adjustment of valbenazine or more frequent monitoring by your doctor to safely use both valbenazine and grapefruit products. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Major

encorafenib food

Applies to: Braftovi (encorafenib)

You should preferably avoid consumption of grapefruit and grapefruit juice while taking encorafenib. Grapefruit and grapefruit juice can significantly increase the blood levels of encorafenib. This may increase the risk of serious side effects such as bleeding complications, eye and vision problems, liver problems, irregular heart rhythm, and development of new skin cancers. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.