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Drug Interactions between berotralstat and letermovir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

letermovir berotralstat

Applies to: letermovir and berotralstat

GENERALLY AVOID: Coadministration with inducers of P-glycoprotein (P-gp) may significantly decrease the plasma concentrations and pharmacologic effects of berotralstat, a substrate of this efflux transporter. Clinical data evaluating this interaction are not available.

MANAGEMENT: Due to the potential for diminished pharmacologic effects of berotralstat, its concomitant use with P-gp inducers, including but not limited to rifampin and St. John's wort, should be avoided. Alternative therapeutic agents with less P-gp induction potential should be considered whenever possible.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2021) "Product Information. Orladeyo (berotralstat)." BioCryst Pharmaceuticals Inc

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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