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Drug Interactions between Benlysta and bortezomib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

bortezomib belimumab

Applies to: bortezomib and Benlysta (belimumab)

Consumer information for this interaction is not currently available.

MONITOR: Concomitant use of belimumab and rituximab may lead to an increase in the rate of severe adverse events and serious infections. Belimumab therapy alone has been associated with serious and sometimes fatal infections. In a double-blind, randomized, placebo-controlled, phase 3 trial in adults with systemic lupus erythematosus (SLE) receiving belimumab, the addition of rituximab was associated with serious adverse events in 22.2% and serious infections in 9% of patients, compared to 13.9% and 2.8% of patients, respectively, in the placebo add-on group. Clinical data are not available for other B-cell targeted therapies.

MANAGEMENT: According to the manufacturer of belimumab, available data do not support the coadministration of belimumab with rituximab in patients with SLE. Caution and monitoring for adverse reactions, particularly infections, is advised if concomitant use of belimumab with other biologic therapies with immunosuppressant effects, particularly B-cell targeted therapies including but not limited to ocrelizumab, ofatumumab, or obinutuzumab. Some authorities advise against their concomitant use.

Drug and food interactions

Moderate

bortezomib food

Applies to: bortezomib

Limited evidence suggest that green tea may interfere with the antitumor effects of bortezomib. Until more information is available, it may be best to avoid or limit the consumption of green tea and green tea products during treatment with bortezomib. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.