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Drug Interactions between Belviq and Denzapine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

cloZAPine lorcaserin

Applies to: Denzapine (clozapine) and Belviq (lorcaserin)

Using lorcaserin together with cloZAPine may increase the risk of a rare but serious condition called the neuroleptic malignant syndrome, which may include symptoms such as agitation, confusion, delusion, hallucination, extreme changes in blood pressure, excessive sweating, fever, shivering or shaking, restlessness, muscle spasm or stiffness, tremor, and incoordination. Severe cases may result in coma and even death. You should contact your doctor immediately if you experience these symptoms while taking the medications. In addition, both lorcaserin and cloZAPine, especially when given long-term, can cause increases in the levels of a hormone called prolactin. The health effects of high levels of prolactin are not known; however, some patients (including men) have experienced increased breast size and milk or milky discharge from the breasts. Some breast cancers may also be dependent on prolactin; therefore, let your doctor know if you have a history of breast cancer. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

cloZAPine food

Applies to: Denzapine (clozapine)

Alcohol can increase the nervous system side effects of cloZAPine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cloZAPine. Do not use more than the recommended dose of cloZAPine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Minor

lorcaserin food

Applies to: Belviq (lorcaserin)

Information for this minor interaction is available on the professional version.

Minor

cloZAPine food

Applies to: Denzapine (clozapine)

Information for this minor interaction is available on the professional version.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.