Drug Interactions between Bactrim and simeprevir
This report displays the potential drug interactions for the following 2 drugs:
- Bactrim (sulfamethoxazole/trimethoprim)
- simeprevir
Interactions between your drugs
No interactions were found between Bactrim and simeprevir. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Bactrim
A total of 412 drugs are known to interact with Bactrim.
- Bactrim is in the drug class sulfonamides.
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Bactrim is used to treat the following conditions:
- Bacterial Infection
- Bacterial Skin Infection
- Bronchitis
- Diverticulitis
- Epiglottitis
- Granuloma Inguinale
- Infection Prophylaxis
- Kidney Infections
- Melioidosis
- Meningitis
- Nocardiosis
- Otitis Media
- Pneumocystis Pneumonia
- Pneumocystis Pneumonia Prophylaxis
- Pneumonia
- Prevention of Bladder infection
- Prostatitis
- Shigellosis
- Sinusitis
- Toxoplasmosis
- Toxoplasmosis, Prophylaxis
- Traveler's Diarrhea
- Upper Respiratory Tract Infection
- Urinary Tract Infection
simeprevir
A total of 191 drugs are known to interact with simeprevir.
- Simeprevir is in the drug class protease inhibitors.
- Simeprevir is used to treat Hepatitis C.
Drug and food interactions
simeprevir food
Applies to: simeprevir
ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of simeprevir, although the type of food does not seem to matter. In healthy study subjects, administration of simeprevir after a high-fat, high-caloric (928 kcal) breakfast increased systemic exposure (AUC) by 61% and delayed absorption by 1 hour, while administration after a normal caloric (533 kcal) breakfast increased AUC by 69% and delayed absorption by 1.5 hours.
MANAGEMENT: To ensure maximal oral absorption, simeprevir should be administered with food.
References
- (2013) "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals
sulfamethoxazole food
Applies to: Bactrim (sulfamethoxazole / trimethoprim)
MONITOR: Two cases have been reported in which patients on sulfamethoxazole-trimethoprim therapy, after consuming beer, reported flushing, heart palpitations, dyspnea, headache, and nausea (disulfiram - alcohol type reactions). First-generation sulfonylureas have been reported to cause facial flushing when administered with alcohol by inhibiting acetaldehyde dehydrogenase and subsequently causing acetaldehyde accumulation. Since sulfamethoxazole is chemically related to first-generation sulfonylureas, a disulfiram-like reaction with products containing sulfamethoxazole is theoretically possible. However, pharmacokinetic/pharmacodynamic data are lacking and in addition, the two reported cases cannot be clearly attributed to the concomitant use of sulfamethoxazole-trimethoprim and alcohol.
MANAGEMENT: Patients should be alerted to the potential for this interaction and although the risk for this interaction is minimal, caution is recommended while taking sulfamethoxazole-trimethoprim concomitantly with alcohol.
References
- Heelon MW, White M (1998) "Disulfiram-cotrimoxazole reaction." Pharmacotherapy, 18, p. 869-70
- Mergenhagen KA, Wattengel BA, Skelly MK, Clark CM, Russo TA (2020) "Fact versus fiction: a review of the evidence behind alcohol and antibiotic interactions." Antimicrob Agents Chemother, 64, e02167-19
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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