Drug Interactions between avanafil and Lamprene
This report displays the potential drug interactions for the following 2 drugs:
- avanafil
- Lamprene (clofazimine)
Interactions between your drugs
clofazimine avanafil
Applies to: Lamprene (clofazimine) and avanafil
Consumer information for this interaction is not currently available.
ADJUST DOSE: Coadministration with moderate inhibitors of CYP450 3A4 may increase the plasma concentrations of avanafil, which is primarily metabolized by the isoenzyme. In 15 healthy male volunteers, administration of a single 200 mg dose of avanafil following pretreatment with the moderate CYP450 3A4 inhibitor erythromycin (500 mg twice daily for 5 days) increased avanafil peak plasma concentration (Cmax) and systemic exposure (AUC) by approximately 2-fold and 3.6-fold, respectively, compared to administration of avanafil alone. Erythromycin also prolonged the half-life of avanafil to approximately 8 hours, from a normal of 5 hours.
MANAGEMENT: The dosage of avanafil should not exceed 50 mg once every 24 hours when used in combination with moderate CYP450 3A4 inhibitors.
References
- (2012) "Product Information. Stendra (avanafil)." Vivus Inc
Drug and food interactions
avanafil food
Applies to: avanafil
Avanafil can lower blood pressure, and combining it with alcohol may further increase this effect. You may be more likely to experience symptoms such as dizziness, lightheadedness, fainting, flushing, headache, and heart palpitations. You should avoid or limit the use of alcohol while being treated with avanafil, and use caution when getting up from a sitting or lying position. You may also want to avoid drinking large amounts of grapefruit juice, since it may increase the blood levels and effects of avanafil. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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