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Drug Interactions between atropine and macimorelin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

atropine macimorelin

Applies to: atropine and macimorelin

GENERALLY AVOID: Drugs that may blunt the growth hormone response to macimorelin such as muscarinic antagonists (e.g., atropine), anti-thyroid agents (e.g., propylthiouracil), and growth hormone products may impact the accuracy of the macimorelin diagnostic test.

MANAGEMENT: Concomitant use of drugs that can blunt the response to macimorelin should generally be avoided. A sufficient washout period following discontinuation of these drugs is recommended prior to macimorelin administration. The prescribing information recommends discontinuing growth hormone products for at least one week before administering the macimorelin diagnostic test.

References (1)
  1. (2018) "Product Information. Macrilen (macimorelin)." Aeterna Zentaris

Drug and food interactions

Moderate

macimorelin food

Applies to: macimorelin

ADJUST DOSING INTERVAL: Food reduces the oral bioavailability of macimorelin. According to the product labeling, administration with a liquid meal decreased macimorelin peak plasma concentration (Cmax) and systemic exposure (AUC) by 55% and 49%, respectively, compared to administration under fasting conditions (i.e., for at least 8 hours).

MANAGEMENT: Macimorelin should be administered after fasting for at least 8 hours.

References (1)
  1. (2018) "Product Information. Macrilen (macimorelin)." Aeterna Zentaris
Moderate

atropine food

Applies to: atropine

GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.

MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.

References (1)
  1. Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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