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Drug Interactions between atazanavir / cobicistat and Rescriptor

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

delavirdine atazanavir

Applies to: Rescriptor (delavirdine) and atazanavir / cobicistat

Delavirdine may increase the blood levels and effects of atazanavir. This may increase the risk and/or severity of side effects such as jaundice, kidney stones, gallstones, high blood sugar, diabetes, and irregular heartbeat. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop yellowing of the skin or eyes, pain in your side or lower back, painful urination, blood in your urine, abdominal pain or tenderness, or sudden dizziness, lightheadedness, fainting, or a slow heart rate during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

delavirdine cobicistat

Applies to: Rescriptor (delavirdine) and atazanavir / cobicistat

Cobicistat is a medication used to boost the effects of some medications that treat HIV infection. However, using cobicistat together with other HIV medications, such as delavirdine, may alter the blood levels and effects of both medications. Using delavirdine with cobicistat may reduce or increase blood levels of cobicistat. Reduced blood levels of cobicistat may make cobicistat less effective and may cause overall HIV treatment to be less effective. Cobicistat may increase blood levels of delavirdine which may increase the risk of side effects. Talk to your doctor or pharmacist if you have any questions on how to use these medications properly. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

atazanavir food

Applies to: atazanavir / cobicistat

Food can enhance the levels of atazanavir in your body. To ensure maximal oral absorption, atazanavir should be administered with or immediately after a meal. This will make it easier for your body to absorb the medication.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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