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Drug Interactions between asenapine and deferasirox

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

deferasirox asenapine

Applies to: deferasirox and asenapine

MONITOR: Coadministration with inhibitors of CYP450 1A2 may increase the plasma concentrations of asenapine, which is partially metabolized by the isoenzyme. According to the product labeling, administration of asenapine (5 mg single dose) in combination with the potent CYP450 1A2 inhibitor fluvoxamine (25 mg twice daily for 8 days) resulted in a 13% increase in asenapine peak plasma concentration (Cmax) and a 29% increase in systemic exposure (AUC). The full therapeutic dose of fluvoxamine would be expected to cause a greater increase in asenapine plasma concentrations.

MANAGEMENT: Caution is advised if asenapine is prescribed in combination with CYP450 1A2 inhibitors. Pharmacologic response to asenapine should be monitored more closely whenever a CYP450 1A2 inhibitor is added to or withdrawn from therapy, and the asenapine dosage adjusted as necessary.

References

  1. (2009) "Product Information. Saphris (asenapine)." Schering-Plough Corporation

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Drug and food interactions

Moderate

deferasirox food

Applies to: deferasirox

ADJUST DOSING INTERVAL: According to product labeling, the bioavailability of deferasirox was variably increased when taken with a meal.

MANAGEMENT: To ensure consistent plasma drug levels, deferasirox should be taken on an empty stomach 30 minutes before eating preferably at the same time everyday.

References

  1. (2005) "Product Information. Exjade (deferasirox)." Novartis Pharmaceuticals

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Moderate

asenapine food

Applies to: asenapine

GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

References

  1. Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
  2. Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
  3. (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
  4. (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
View all 4 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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