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Drug Interactions between Aricept and succinylcholine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

succinylcholine donepezil

Applies to: succinylcholine and Aricept (donepezil)

MONITOR: Acetylcholinesterase inhibitors may prolong and/or enhance the muscle relaxation effects of succinylcholine by blocking the activity of plasma cholinesterase, the enzyme responsible for the hydrolysis of succinylcholine. Prolonged neuromuscular blockade and respiratory depression may occur.

MANAGEMENT: It may be appropriate to discontinue acetylcholinesterase inhibitor therapy for a few days before the procedure depending on the needs of the patient. Otherwise, the patient should be monitored closely for increased pharmacologic effects of succinylcholine. Peripheral nerve stimulators are recommended for accurate assessment of neuromuscular blockade in patients who have been taking pyridostigmine.

References (6)
  1. Freeman SE, Dawson RM (1991) "Tacrine: a pharmacological review." Prog Neurobiol, 36, p. 257-77
  2. (2001) "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals
  3. (2001) "Product Information. Reminyl (galantamine)." Janssen Pharmaceuticals
  4. Keeler JR (1990) "Interactions between nerve agent pretreatment and drugs commonly used in combat anesthesia." Mil Med, 155, p. 527-33
  5. Heath ML (2003) "Donepezil and succinylcholine." Anaesthesia, 58, p. 202
  6. (2024) "Product Information. Zunveyl (benzgalantamine)." Alpha Cognition, Inc., SUPPL-1

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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