Drug Interactions between amitriptyline and Zepatier
This report displays the potential drug interactions for the following 2 drugs:
- amitriptyline
- Zepatier (elbasvir/grazoprevir)
Interactions between your drugs
No interactions were found between amitriptyline and Zepatier. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
amitriptyline
A total of 706 drugs are known to interact with amitriptyline.
- Amitriptyline is in the drug class tricyclic antidepressants.
-
Amitriptyline is used to treat the following conditions:
- Anxiety and Stress (off-label)
- Burning Mouth Syndrome (off-label)
- Chronic Myofascial Pain (off-label)
- Chronic Pain
- Cough (off-label)
- Cyclic Vomiting Syndrome (off-label)
- Depression
- Depressive Psychosis (off-label)
- Dysautonomia (off-label)
- Fibromyalgia (off-label)
- Headache
- Hyperhidrosis (off-label)
- Insomnia (off-label)
- Interstitial Cystitis (off-label)
- Irritable Bowel Syndrome (off-label)
- Migraine
- Migraine Prevention (off-label)
- Neuropathic Pain (off-label)
- Neurotic Depression (off-label)
- Pain (off-label)
- Persistent Depressive Disorder (off-label)
- Post Traumatic Stress Disorder (off-label)
- Pudendal Neuralgia (off-label)
- Reflex Sympathetic Dystrophy Syndrome (off-label)
- Somatoform Pain Disorder (off-label)
- Urinary Incontinence (off-label)
- Vulvodynia (off-label)
Zepatier
A total of 227 drugs are known to interact with Zepatier.
- Zepatier is in the drug class antiviral combinations.
- Zepatier is used to treat Hepatitis C.
Drug and food interactions
amitriptyline food
Applies to: amitriptyline
GENERALLY AVOID: Concomitant use of ethanol and a tricyclic antidepressant (TCA) may result altered TCA plasma levels and efficacy, and additive impairment of motor skills, especially driving skills. Acute ethanol ingestion may inhibit TCA metabolism, while chronic ingestion of large amounts of ethanol may induce hepatic TCA metabolism.
MANAGEMENT: Patients should be advised to avoid alcohol during TCA therapy. Alcoholics who have undergone detoxification should be monitored for decreased TCA efficacy. Dosage adjustments may be required.
References
- Dorian P, Sellers EM, Reed KL, et al. (1983) "Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction." Eur J Clin Pharmacol, 25, p. 325-31
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Sandoz M, Vandel S, Vandel B, Bonin B, Allers G, Volmat R (1983) "Biotransformation of amitriptyline in alcoholic depressive patients." Eur J Clin Pharmacol, 24, p. 615-21
- Ciraulo DA, Barnhill JG, Jaffe JH (1988) "Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers." Clin Pharmacol Ther, 43, p. 509-18
- Seppala T, Linnoila M, Elonen E, Mattila MJ, Makl M (1975) "Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving." Clin Pharmacol Ther, 17, p. 515-22
- Ciraulo DA, Barnhill JG, Jaffe JH, Ciraulo AM, Tarmey MF (1990) "Intravenous pharmacokinetics of 2-hydroxyimipramine in alcoholics and normal controls." J Stud Alcohol, 51, p. 366-72
- Ciraulo DA, Alderson LM, Chapron DJ, Jaffe JH, Subbarao B, Kramer PA (1982) "Imipramine disposition in alcoholics." J Clin Psychopharmacol, 2, p. 2-7
grazoprevir food
Applies to: Zepatier (elbasvir / grazoprevir)
Food does not appear to have clinically significant effects on the pharmacokinetics of elbasvir and grazoprevir. When a single 50 mg-100 mg dose of elbasvir-grazoprevir was administered to healthy study subjects with a high-fat meal (900 kcal; 500 kcal from fat), elbasvir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 15% and 11%, respectively, while grazoprevir Cmax and AUC increased by 2.8- and 1.5-fold, respectively, compared to administration under fasting conditions. According to the product labeling, elbasvir-grazoprevir may be administered with or without food.
References
- (2016) "Product Information. Zepatier (elbasvir-grazoprevir)." Merck & Co., Inc
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.