Drug Interactions between amitriptyline / perphenazine and linezolid

If you are currently being treated with amitriptyline, let your doctor know before you receive linezolid. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. Depending on your condition, your doctor may want you to discontinue amitriptyline before you start treatment with linezolid, or prescribe an alternative medication. Otherwise, you will need to be closely monitored by your doctor during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Before taking amitriptyline, tell your doctor if you also use perphenazine. You may need dose adjustments or special tests in order to safely take both medications together. This combination should be used with caution, particularly in the elderly. You should notify your doctor promptly if you have signs of bladder problems, dry mouth, stomach pain, fever, blurred vision, confusion, dizziness, or reduced heart rate. You should avoid driving until you know how these medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

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Using perphenazine together with linezolid can increase the side effects of both medications. You may be more likely to develop low blood pressure and related problems such as dizziness, lightheadedness, fainting, weakness, and a rapid pulse/heart rate. Nervous system side effects such as drowsiness, confusion, disorientation, memory loss, and seizures may also increase. Let your doctor know if you experience these symptoms and they do not go away after a few days or they become troublesome. These side effects can occur with either medication alone and are most often seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Alcohol may also increase these effects, so you should avoid the consumption of alcohol during treatment with these medications. You should seek immediate medical attention if you develop fever, muscle stiffness, confusion, sweating, fast or uneven heartbeats, restless muscle movements in your face or neck, tremor (uncontrolled shaking), or difficulty swallowing. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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