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Drug Interactions between amantadine and trimethoprim

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

amantadine trimethoprim

Applies to: amantadine and trimethoprim

MONITOR: Trimethoprim may decrease the renal clearance of amantadine and memantine. The mechanism may be competition for organic cation transporter-2 (OCT-2)-mediated secretion in the kidney tubule of which amantadine, memantine, and trimethoprim are substrates. Trimethoprim may also inhibit OCT-2. Increased levels of amantadine and memantine may increase the risk of neurological side effects such as mental confusion, delirium, and myoclonus. Serum trimethoprim levels may also be increased.

MANAGEMENT: Caution and monitoring for nervous system side effects is recommended if trimethoprim is used with either amantadine or memantine. Patients should be advised to contact their physician if they experience nervous system side effects such as mental confusion and myoclonus.

References (5)
  1. Speeg KV, Leighton JA, Maldonado AL (1989) "Case report: toxic delirium in a patient taking amantadine and trimethoprim sulfamethoxazole." Am J Med Sci, 298, p. 410-2
  2. (2022) "Product Information. Bactrim (sulfamethoxazole-trimethoprim)." Roche Laboratories
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  4. Cerner Multum, Inc. "Australian Product Information."
  5. Moellentin D, Picone C, Leadbetter E (2008) "Memantine-induced myoclonus and delirium exacerbated by trimethoprim." Ann Pharmacother, 42, p. 449-7

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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