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Drug Interactions between alprazolam and Opana

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

ALPRAZolam oxyMORphone

Applies to: alprazolam and Opana (oxymorphone)

Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including profound sedation, respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, because these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed and motor coordination, you should avoid driving or operating hazardous machinery until you know how they affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food/lifestyle interactions

Major

oxyMORphone food/lifestyle

Applies to: Opana (oxymorphone)

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Consumption of alcohol while taking immediate- or extended-release formulations of oxymorphone may result in high systemic levels of oxymorphone and fatal overdose even in opioid-tolerant patients. Additionally, alcohol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics including oxymorphone. Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.

ADJUST DOSING INTERVAL: After oral dosing with 40 mg of oxymorphone hydrochloride in healthy volunteers under fasting conditions or with a high-fat meal, the maximum plasma concentration (Cmax) and systemic exposure (AUC) of oxymorphone were increased by approximately 38% in fed subjects compared to fasted subjects.

MANAGEMENT: Patients taking opioid analgesics including oxymorphone should not consume alcohol or use medications that contain alcohol. Modified and/or extended-release oxymorphone formulations must also be swallowed whole and not crushed, chewed or divided. In addition, oxymorphone should be administered on an empty stomach, at least 1 hour before or 2 hours after food intake.

Moderate

ALPRAZolam food/lifestyle

Applies to: alprazolam

Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Do not drink alcohol while taking ALPRAZolam. This medication can increase the effects of alcohol. You may feel more drowsy, dizzy, or tired if you take ALPRAZolam with alcohol. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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