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Drug Interactions between alfuzosin and midodrine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

midodrine alfuzosin

Applies to: midodrine and alfuzosin

GENERALLY AVOID: Midodrine, an alpha agonist, when used in combination with alpha adrenergic blockers may lead to a decreased therapeutic effect in some patients. The mechanism is due to pharmacologic antagonism at the alpha adrenoreceptor.

MANAGEMENT: Alpha adrenergic blockers should be avoided, if possible, in patients taking midodrine for orthostatic hypotension.

References (3)
  1. (2001) "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation
  2. (2002) "Product Information. Xatral (alfuzosin)." Sanofi-Synthelabo Canada Inc
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Drug and food interactions

Moderate

alfuzosin food

Applies to: alfuzosin

ADJUST DOSING INTERVAL: Administration of alfuzosin with food enhances oral bioavailability. According to the manufacturer, extent of absorption is 50% higher when administered under fed conditions compared to fasting conditions.

MANAGEMENT: To ensure maximal oral absorption, alfuzosin should be administered with or immediately after a meal.

References (1)
  1. (2003) "Product Information. Uroxatral (alfuzosin)." sanofi-aventis

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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