Drug Interactions between aldesleukin and Intron A

Talk to your doctor before using aldesleukin together with interferon alfa-2b. Combining these medications may increase the risk of serious side effects such as heart attack, inflammation of the heart, other heart problems, and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. Let your doctor know immediately if you have unexplained muscle pain, tenderness or weakness, especially if these symptoms are accompanied by fever or dark-colored urine. You should also seek immediate medical attention if you experience chest pain, chest tightness, shortness of breath, difficulty breathing, or irregular heartbeat. Occasionally, using these medications together or one after the other has also been associated with serious allergic reactions. You should be monitored closely by your doctor for signs of a reaction so that emergency treatment may be administered if necessary. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.