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Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) Drug Interactions

A total of 1064 drugs are known to interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

  • 241 major drug interactions
  • 787 moderate drug interactions
  • 36 minor drug interactions

Show all medications in the database that may interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

Check for interactions

Type in a drug name to check for interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

Most frequently checked interactions

View interaction reports for Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) and the medicines listed below.

  • Advil (ibuprofen)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Moxilin, Wymox, Biomox)
  • Azithromycin Dose Pack (azithromycin)
  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Buproban, Budeprion, Aplenzin, Forfivo XL, Budeprion XL, Budeprion SR)
  • Crestor (rosuvastatin)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Sominex, Sleep Tabs, Benadryl Children's Allergy, Dicopanol, Diphen, Nytol, Simply Sleep, Diphenhist, Hydramine, Diphenydramine Quick Melt, Sleepwell 2-nite, Hydramine Cough Syrup, Bydramine, Diphedryl, DPH, Calm-Aid, Diphenadryl, Sleep Tab II, Diphenyl, Altaryl, Quenalin, Diphendryl, Sleep-ettes D, Dytan, Vanamine PD, Unisom SleepMelts, Dormin, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, 40 Winks, Diphen AF, Diphen Cough, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lexapro (escitalopram)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • Mucinex DM (dextromethorphan / guaifenesin)
  • multivitamin (Daflon, Metanx, Neurobion, Vitamins, Theragran, Vitamin B Complex 100, Cerefolin NAC, Cerefolin, Rena-Vite, Folbic, Foltx, Estroven, Nephro-Vite, Lipoflavonoid, Folbee, Foltanx, Thera, Super B Complex, MVI Adult, Nephrocaps, PoDiaPN, Folic Acid XTRA, Tab-A-Vite, Cod Liver Oil Mint, B Complex 100, Triphrocaps, FaBB, Nufola, Nephro-Vite Rx, Cod Liver Oil, Multi Vitamin+, Rheumate, Renal Caps, Essentiale, Berocca, Daily Vite, Rena-Vite Rx, Xyzbac, Lysiplex, Flintstones Multivitamins, Surbex, Super B-50, Fletanol, Infuvite, Infuvite Pediatric, Folcaps, Folinic-Plus, StressTabs, Reno Caps, Surbex with C, Folika-T, Apetigen, Stress Formula, B Complex 50, Cernevit, Vitamin Daily Liquid, Topfit Vitamin B Complex, Vitamin B Compound Strong, Nephronex, Folgard RX, One-A-Day Men's Health Formula, Folplex, Nephplex Rx, Metafolbic Plus, Virt-Caps, Therems, Daily Multiple Vitamins, Childrens Chewable Multivitamins, Vitacirc-B, One-A-Day Essentials, Essential Balance, Flintstones with C Multivitamins, Stress B with C, Theravite, Thera-Plus, High Potency B Complex with B12 and C, Super B-100 TD, L-methylfolate Ca, Me-Cbl NAC, Theragenerix, Apetex, Folastin, Topfit Vitamin B Complex Forte, L-Methyl-B6-B12, Jetepar, Vitamin A and D Concentrate, Centrum 8400, Foltabs 800, Menopause Relief with Lifenol, Daily-Vite Men's Formula, Biotin Forte, Vimar, B 100 Complex, Vol-Care Rx, Folbic RF, Foltanx RF, Mebolex, Mebolic, B-Plex, Vitaplex, Metafolbic, Stress-600, Thera-Tabs, Vi-Daylin, Poly-Vi-Sol, Watkins Harvest, Balanced B-100, B-Stress, B-Scorbic, Bee with C, Balanced B-50, Nat-Rul B-125, Balanced B-150, Unicap Capsule, Unicap Jr, Unicap, Optilets-500, Super Plenamins, Vitamins for Hair, Vi-Daylin Chewable, Folast, Enfolast, Sunkist Child Chewable with C, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Fruity Chew, Triphro, Poly-Vit Chew, Vita-Respa, Chewable-Vite, Bugs Bunny with Extra C, Geravine, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Poly-Vi-Sol Drops, Baby Vitamin Drop, Vita Drop, Poly Vit Drops, MVC SDV, Glutofac, Allbee-C, Vitabee with C, High Potency B+C, Av-VITE FB, Farbee with C, Mynephron, Renatabs, Tri-Vitamin, DEKAs Essential, Vitamin B-50, Vitamin B-100, D-400 international units, Vitamin B-100 T/R, Hexavitamin, Celebrate B-12, Kenwood Therapeutic, Oncovite, Glycogenics, Beminal-500, Tri-Vit Drops, Flintstones Toddler, One Tab Daily, Vitamin C, E, and Rose Hips, Scotts Emulsion, Stress Formula 600, Tri-Vit, Mega B, Apatate, T-Vites, Hylavite, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Prostate 2.4, MTX Support, Cardiotek, Beminal, Beminal with C Fortis, Full Spectrum B with C, Bugs Bunny Multiple Vitamins, Allbee with C, Prevital, Surbex Filmtab, Tender Age Vitamin ADC, Folgard Rx 2.2, Cernevit-12, SeroSyn, Diatx, Vitamin A, D, One-A-Day 50+, Thex Forte, Metafolbic Plus RF, Dosoquin, Protegra Cardio, Virt-Vite Plus, K2 Plus D3, Renaphro, Virt-Gard, Dialyvite Rx, L-Methyl-MC, Levomefolate Calcium-Algal Powder, VP-Vite Rx, Vesselvite, Folbee Plus, Combgen, Abidec, Unichem Multivitamin, Health Aid Multivitamin, AllanTex, One Daily Multi-Essential, Larobec, Foltrate, Cardiotek Rx, Folbalin Plus, Dialyvite 800, Folbalin, Multi-Delyn, Multi Vits with Beta Carotene, Foleve Plus, Folnate, Folnate Plus, B-Complex with B-12, Foleve, Hair, Skin, & Nails Gummies, Folamin, DexFol, Equaline One Daily Essential, Av-VITE FB Forte, Folmor, Zycose, Vigomar Forte, Allbee Plus, Triveen-CF, Nature's Bounty Hair Skin & Nails, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Methazel, Dyzbac, Mynephrocaps, Omega Q Plus, Acnepril, Super Theravite-M, Primaplex, Becomject-100, Poly-Vita Drops, MVI-12, B-Ject 100, L-Methyl-MC NAC, Therobec, Formula B, Tri-Vi-Sol, TL Gard, Vi-Daylin ADC, Lipogen, Nephrocaps QT, Virt-Vite, Lipotriad, Virt-Vite Forte, Folplex 2.2, Cholinoid, Tri-Vita Drops, Liponol, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, 1000 BC, Neurodep, Neuroforte-Six, MVI Pediatric, B-Plex Plus, Nephrolan Rx, Ivites Rx, Zymacap, Dayalets, Sigtab, Allbee-C 800, Cefol, B-Complex SR, Protegra, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Superplex-T, Vi-Stress, T-BMP, Animal Shape Vitamins, B-50 Complex, Niva-Fol)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) disease interactions

There are 15 disease interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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