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Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) Drug Interactions

A total of 1060 drugs are known to interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

  • 241 major drug interactions
  • 783 moderate drug interactions
  • 36 minor drug interactions

Show all medications in the database that may interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

Check for interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

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Common medications checked in combination with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

  • Advil (ibuprofen)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Moxilin, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Wymox, Biomox)
  • Azithromycin Dose Pack (azithromycin)
  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Buproban, Budeprion, Forfivo XL, Aplenzin, Budeprion SR, Budeprion XL)
  • Crestor (rosuvastatin)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Unisom SleepGels, Diphenhist, Sleep, Dicopanol, Diphenadryl, Sominex, Diphen, Diphedryl, Hydramine, Allermax, Nytol, Benadryl Children's Allergy, Diphenydramine Quick Melt, Pharbedryl, Buckley's Bedtime, Hyrexin, Diphen Cough, DPH, Allergia-C, Q-Dryl, Sleep-Eze-3, Valu-Dryl, Diphenyl, Beldin, Sleep-ettes, Diphendryl, Q-Dryl A/F, Tranquil Nighttime Sleep Aid, Dormin, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Hydramine Cough Syrup, Bydramine, 40 Winks, Diphen AF, Aler-Dryl, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep Tabs, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Quenalin, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Histaprin, Z-Sleep, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Children's Motrin, Motrin Migraine Pain, Advil Migraine, Caldolor, Ibuprofen PMR, Advil Children's, Addaprin, NeoProfen, Advil Infant's Concentrated Drops, A-G Profen, Motrin Childrens, Childrens Ibuprofen Berry, Ibu-6, Ibu-8, Motrin Infant Drops, Ibu-Tab, Rufen, Genpril, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lexapro (escitalopram)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Lopressor, Toprol-XL, Kapspargo Sprinkle)
  • Mucinex DM (dextromethorphan / guaifenesin)
  • multivitamin (Metanx, Daflon, Theragran, Rena-Vite, Folbic, Estroven, Neurobion, Cerefolin, Nephro-Vite, Vitamins, Nephrocaps, Multi Vitamin+, Folbee, B Complex 100, Lipoflavonoid, Cod Liver Oil, Foltx, Foltanx, Vitamin B Complex 100, PoDiaPN, Daily Multiple Vitamins, Thera, Super B Complex, Renal Caps, Cod Liver Oil Mint, Folic Acid XTRA, Tab-A-Vite, Chewable-Vite, Rheumate, Infuvite, Cerefolin NAC, One-A-Day 50+, Xyzbac, Nephplex Rx, Daily Vite, B Complex 50, Essentiale, Foltrate, Reno Caps, Flintstones Multivitamins, Rena-Vite Rx, Topfit Vitamin B Complex, Berocca, Lysiplex, Surbex, Triphrocaps, Cernevit, MVI Adult, Folinic-Plus, Nephronex, TL Gard, Nephro-Vite Rx, Lipogen, Poly-Vi-Sol, Therems, B-Stress, Oncovite, Scotts Emulsion, Theragenerix, Prostate 2.4, MTX Support, Fletanol, Abidec, Topfit Vitamin B Complex Forte, Folgard RX, FaBB, One-A-Day Men's Health Formula, Vol-Care Rx, Foltanx RF, Mebolic, Metafolbic, Metafolbic Plus, Virt-Vite, Folplex 2.2, Ivites Rx, Protegra, Balanced B-50, Essential Balance, Folast, Sunkist Child Chewable with C, Fruity Chew, Poly Vit Drops, Mynephron, Vitamin B-100, Celebrate B-12, Apetigen, One Tab Daily, Vitamin C, E, and Rose Hips, Mega B, Cardiotek, Bugs Bunny Multiple Vitamins, Tender Age Vitamin ADC, Vitamin A, D, Vitamin Daily Liquid, L-Methyl-MC, Levomefolate Calcium-Algal Powder, Folbee Plus, Vitamin A and D Concentrate, Centrum 8400, Folbalin, Hair, Skin, & Nails Gummies, Daily-Vite Men's Formula, Folplex, B 100 Complex, Nature's Bounty Hair Skin & Nails, Nufola, Primaplex, Tri-Vi-Sol, Virt-Vite Forte, Virt-Caps, 1000 BC, Neurodep, StressTabs, Cefol, Watkins Harvest, Balanced B-100, B-Scorbic, Bee with C, Childrens Chewable Multivitamins, Nat-Rul B-125, Balanced B-150, Unicap Capsule, Unicap Jr, Vitacirc-B, Unicap, Optilets-500, Super Plenamins, Vitamins for Hair, One-A-Day Essentials, Vi-Daylin Chewable, Enfolast, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Triphro, Poly-Vit Chew, Vita-Respa, Bugs Bunny with Extra C, Flintstones with C Multivitamins, Geravine, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Poly-Vi-Sol Drops, Baby Vitamin Drop, Vita Drop, MVC SDV, Glutofac, Allbee-C, Vitabee with C, Stress B with C, High Potency B+C, Av-VITE FB, Farbee with C, Surbex with C, Renatabs, Tri-Vitamin, DEKAs Essential, Vitamin B-50, Folika-T, D-400 international units, Vitamin B-100 T/R, Hexavitamin, Kenwood Therapeutic, Theravite, Thera-Plus, Glycogenics, Beminal-500, High Potency B Complex with B12 and C, Super B-50, Super B-100 TD, Tri-Vit Drops, Stress Formula, Flintstones Toddler, Stress Formula 600, Tri-Vit, Apatate, T-Vites, L-methylfolate Ca, Me-Cbl NAC, Hylavite, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Beminal, Beminal with C Fortis, Full Spectrum B with C, Allbee with C, Prevital, Surbex Filmtab, Folgard Rx 2.2, Cernevit-12, SeroSyn, Infuvite Pediatric, Diatx, Thex Forte, Metafolbic Plus RF, Protegra Cardio, Virt-Vite Plus, Renaphro, Apetex, Virt-Gard, Dialyvite Rx, Folastin, Vesselvite, Folcaps, Combgen, Unichem Multivitamin, Vitamin B Compound Strong, L-Methyl-B6-B12, Health Aid Multivitamin, AllanTex, Jetepar, One Daily Multi-Essential, Larobec, Cardiotek Rx, Folbalin Plus, Dialyvite 800, Multi-Delyn, Multi Vits with Beta Carotene, Foleve Plus, Foltabs 800, Folnate, Folnate Plus, B-Complex with B-12, Foleve, Folamin, DexFol, Equaline One Daily Essential, Menopause Relief with Lifenol, Av-VITE FB Forte, Folmor, Zycose, Biotin Forte, Vigomar Forte, Allbee Plus, Vimar, Triveen-CF, Folbic RF, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Mebolex, Methazel, Dyzbac, Mynephrocaps, Omega Q Plus, Acnepril, Super Theravite-M, Becomject-100, Poly-Vita Drops, MVI-12, B-Ject 100, L-Methyl-MC NAC, Therobec, B-Plex, Formula B, Vitaplex, Vi-Daylin ADC, Nephrocaps QT, Lipotriad, Stress-600, Cholinoid, Tri-Vita Drops, Thera-Tabs, Liponol, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, Neuroforte-Six, MVI Pediatric, B-Plex Plus, Nephrolan Rx, Zymacap, Vi-Daylin, Dayalets, Sigtab, Allbee-C 800, B-Complex SR, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Superplex-T, Vi-Stress, T-BMP, Animal Shape Vitamins, B-50 Complex, Niva-Fol)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, Flanax Pain Reliever, Leader Naproxen Sodium, EC-Naprosyn, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) disease interactions

There are 15 disease interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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