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Pain Relief PM Extra Strength (acetaminophen / diphenhydramine) Drug Interactions

A total of 904 drugs are known to interact with Pain Relief PM Extra Strength (acetaminophen / diphenhydramine).

  • 107 major drug interactions
  • 760 moderate drug interactions
  • 37 minor drug interactions

Show all medications in the database that may interact with Pain Relief PM Extra Strength (acetaminophen / diphenhydramine).

Check for interactions with Pain Relief PM Extra Strength (acetaminophen / diphenhydramine)

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Common medications checked in combination with Pain Relief PM Extra Strength (acetaminophen / diphenhydramine)

  • acetaminophen / hydrocodone (Norco, Vicodin, Lortab, Lorcet, Hycet, Vicodin ES, Anexsia, Lorcet Plus, Stagesic, Maxidone, Xodol, Hydrocet, Verdrocet, Vicodin HP, Zamicet, Co-Gesic, Duocet, Duradyne DHC, Hydrogesic, Margesic H, T-Gesic, Zydone, Lorcet HD, Lorcet 10/650, Hy-Phen, Panacet, Vanacet, Dolagesic, Zyfrel, Zolvit, Dolacet, Theracodophen Low 90, Anolor DH5, Liquicet)
  • albuterol (Ventolin, ProAir HFA, Ventolin HFA, Proventil, Proventil HFA, ProAir RespiClick, Respirol, AccuNeb, Vospire ER, Airet, Volmax, ProAir Digihaler)
  • alprazolam (Xanax, Alprazolam Intensol, Xanax XR, Niravam)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Ecotrin Adult Low Strength, Bufferin, Aspiritab, Arthritis Pain, Fasprin, Halfprin, Easprin, Durlaza, Aspirtab, St. Joseph 81 mg Chewable Aspirin, Aspergum, Low Dose ASA, Buffered Aspirin, Ecotrin Maximum Strength, Ascriptin Enteric, Acuprin 81, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Aspirin Lite Coat, Bayer Aspirin Regimen, Aspi-Cor, Empirin, Bayer Children's Aspirin, Bufferin Extra Strength, St. Joseph Aspirin, Bayer Women's Aspirin With Calcium, Miniprin, Migralex, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Ecpirin, Zero-Order Release, YSP Aspirin, Heartline, Bayer Advanced Aspirin, Buffasal)
  • atorvastatin (Lipitor)
  • Calcium 600 D (calcium / vitamin d)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Proprinal, Motrin IB, Children's Motrin, IBU-200, Advil Migraine, Ibu-8, Motrin Childrens, Nuprin, Motrin Migraine Pain, Ibuprofen PMR, NeoProfen, Caldolor, Advil Children's, Addaprin, Motrin Infant Drops, Advil Infant's Concentrated Drops, Rufen, Genpril, A-G Profen, Ibu-Tab, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, Childrens Ibuprofen Berry, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Levothyrox, Euthyrox, Levo-T, L Thyroxine Roche, Eutroxsig, Novothyrox, Oroxine, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • meloxicam (Mobic, Vivlodex, Qmiiz ODT)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • multivitamin with minerals (Centrum, Ocuvite, Centrum Silver, PreserVision, PreserVision AREDS 2, Certa-Vite Senior Plus Lutein, Emergen-C, Airborne, Calcium 600+D Plus Minerals, Ocuvite Lutein, Theragran-M, ICaps AREDS, Calcium Magnesium Potassium, Folgard, Strovite, Hemax, AquADEKs, Antioxid Caplets, Flintstones Complete, Vitamin C plus Zinc, Prosteon, MultiVitamin Plus Zinc, Certa-Vite, Antioxidant Formula, Certagen, Cerovite Advanced Formula, Hemocyte Plus, Centrum Silver Women's, I-Vite, Centrum Adults, Cerovite Senior, Caltrate Plus, Nicotinamide ZCF, Certavite, Nicaprin, RenaPlex, Viactiv Calcium Flavor Glides, AquADEKs Pediatric, Tozal, Thera-M, Actiflovit, RenaPlex-D, Prosight with Lutein, elppa Daily, Vitafol, Viactiv Soft Calcium Chews, Ocuvite Extra, Siderol, MagneBind 400 Rx, MaxFe, High Potency, Ellis Tonic Sherry, Viactiv Multi-Vitamin, Caltrate 600 Plus, Spectravite Senior, Support 500, V-C Forte, Centamin, Therems M, Advanced AM/PM, Centrum Silver Men's, Prosight, Womens Pack, Strovite One, Dolomite, SSS, Spectravite Cardio Health, Eldertonic, Geritol Complete, Citracal Plus Magnesium, Certagen Senior with Lutein, Nicadan, Renax, Nicomide, Centavite, Daily Multi-Vitamins with Minerals, Lipoflavovit, Ocuvite Eye + Multi, Stress with Zinc, ProRenal Vital, PureVit DualFe Plus, Senetonic, Airborne Everyday Gummies, Airborne Gummies, Airborne Plus Energy, Bacmin, Becomax Rx, Betamed, StressTabs with Zinc, Vital-D, Vitatab MV, Centratex, NanoVM, Central-Vite, Celebrate Calcium Plus 500, Central, Apetigen-Plus, 50 + Companion, ICaps Plus, Diavite Plus, TheraLith XR, Supervite, Thyrosol, Mens Pack, Theragener-M, Citracal Plus Bone Density Builder, Vol-Plus, Daily Multiple for Men 50+, Complete Formulation Chewables D3000, Hair Booster, Macular Vitamin Benefit, Multilex-T/M+Minerals, Vicon-C, Corvita, Vitamax, Centrum Specialist Vision, ICaps with Lutein and Zeaxan, Conception XR, Embrex 600, CertaVite with Antioxidants, Ocuvite PreserVision, Folgard OS, NicAzel, Caltrate 600+D Plus Minerals, Renax 5.5, Somnicin, Abatron, Multi-Day Plus Minerals, CertaVite Senior, ABC Plus Senior, Daily-Vite Weight Control, ProRenal QD, Healthy Eyes, Centrum Silver Ultra Men's, Centrum Silver Ultra Women's, elon Matrix 5000 Complete, ICaps Lutein & Omega-3, Centrum Vitamints, Berocca Plus, PureFe Plus, Vicon Forte, Vitatrum, Daily Multi, Magna-C-7 Forte, Macular Health, Zincvit, Centravites 50 Plus, Vica-Forte, Cezin-S, AKEDamins, Eldercaps, Corvita 150, Solo, Vitacon Forte, Caromega, Vita-Min Rx, Advanced Eye Health, Airborne Dual Action, Circavite T, Airborne Everyday, Vitalize Plus, TL G-Fol OS, Therobec Plus, Zodeac-100, Airborne Kids Gummies, Vitaplex Plus, Berplex Plus, Strovite Plus, Vicon Plus, Optilets-M-500, Se-Tan Plus, Fosfree, Surbex-750 with Zinc, SourceCF Multivitamins with A,B,D,E & K plus Zinc, Alka-Seltzer Plus Immunity Complex, SourceCF Softgels, SourceCF Chewables, Recal D, ChoiceFul, SourceCF Pediatric Drops, Rx Support Heartburn and Acid Reflux, CalMag Thins, Zinc Plus Lozenges, Centrum Flavor Burst, Centrum Special Immune, Gevrabon, Sesame St Vitamins Complete, Dialyvite 5000, Macular Health Formula, Century, One-A-Day Within, One-A-Day Men Pro Edge, One-A-Day Vitacraves, Celebrate Multivitamin, ProBarimin QT, B-Plex Plus Minerals, Multigenics, Optivite PMT, Bugs Bunny Complete, Risanoid Plus, ABC to Z, One Tab Daily with Minerals, Bladder 2.2, Centrum Special Energy, Centrum Special Heart, One Daily with Minerals, Companion Multi, One-A-Day Max, ConceptionXR MSF, ConceptionXR RHF, Essentia, Complete Formulation Minis, Century-Vite, Genicin Vita-Q, One-A-Day Women, Genicin Vita-S, Caltrate 600+D Plus Minerals Minis, Calcet Plus, Gerivite Liquid, Lysiplex Plus, Generix-T, NanoVM 1-3 years, Certagen Senior, NanoVM 4-8 years, Decagen, Geri-Tonic, Avail Calcium Intensive, Vita-Dec, Multilex, Vigortol Liquid, Centrum Silver Plus Vision, Cerovite Liquid, Myadec, Req49+, Multi-Day with Calcium and Extra Iron, Flintstones with Calcium, Supervite EC, Magonate Tablets, Therapeutic-M, T-Lite, Dialyvite Supreme D, Unicap M, Gevratonic, Gold Age Liquid Vitamins and Minerals, Theratrum Complete 50 Plus, Unicap Senior, Garfield Complete Vitamins, Z-Bec, Z-Gen, Daily Multiple for Women, Complete Formulation Pediatric Drops, Daily Multiple for Women 50+, Complete Formulation Softgels D3000, Complete Formulation Softgels D5000, Eye Health Formula, TheraCal D2000, Unicap T, TheraCal D4000, TheraCal Rapid Repletion, Viogen-C, Gynovite, PMS Balance, Procycle Multi Vitamin with Minerals, Dialyvite 800 Ultra D, VP-ZEL, Adeks, Stress 600 with Zinc, Leg-Gesic, Stress Formula with Zinc, Theragener-H, Vi-Zac, Centrum Cardio, Vita-Zinc, Renatabs with Iron, Complete Formulation Chewables, Uni-Thera M with Beta Carotene, CertaVite with Lutein, T-Gran plus Minerals, Calcium, Magnesium and Zinc, My-A-Multi, Century Senior, Cerovite Junior, Bee-Zee, Compete, Myvitalife, Formula Twenty-One, Mi-C-T, I-Fol Plus, Thera Hematinic, Flintstones Gummies, ABDEK, I-Sense, Foli-Iron, ABDEK Pediatric, Nicadan ZX, Complete Formulation, Unicomplex M, Complete Formulation D3000, Ru-Lets M 500, Complete Formulation D5000, Apatate Forte, Nu-Iron V, SourceCF ABDEK, L'il Critters Gummy Vites, Daily Combo, Super High Vitamins and Minerals, Corvite Free, Icaps TR, Corvite 150, RE Fac-X, Geritol Extend, Theratrum Complete 50 Plus with Lutein and Lycopene, Theravim M, Companion, Theratrum Complete with Lutein and Lycopene, Beelith, Complete Formulation Softgels, Strovite Forte, ZE-Plus, Glutofac-ZX, MaxiVision Eye & Body Formula, Reocyte Plus, MaxiVision Eye Formula, DermaNIC, L-Tonic, Re Dualvit F, MaxiVision Ocular Formula, DermaVite, Re Dualvit Plus, Glutofac-MX, MaxiVision Whole Body Formula, Nature's Bounty Men's Hair Formula, Mediplex Ultra, Nutiifac ZX, NicAzel Forte, Formula B Plus, Hematinic Plus, ProCerv HP, M-Vit, Support, Vicap Forte, Vita S Forte, Centrum Performance, Protegra Softgel, Strovite Advance, Centravites Adults, I-Sense OccuShield, Tab-A-Vite Maximum, Occuplex, Uni-Fac ZX, Dialyvite with Zinc Rx, Dialyvite 800 with Zinc, CF Vite, Strovite Advance+D, Resource Optisource, Tab-A-Vite Womens Formula, Astamed MYO, Tab-A-Vite WeightSlim, DEKAs Plus, Dialyvite 3000, Udamin, Udamin SP, Vita Zx, CalciFol, Femtabs, Diatx Zn, Complete A-Z, Thera-Vite M, Nutravance, Optisource Post Bariatric Surgery, O-CAL FA, ICaps MV, Men's Hair Formula, Nature's Blend Theratrum Complete Tablets 50 Plus, One-A-Day Mens 50+ Healthy Advantage, Os-Cal Ultra, Puralor Ci with DHA, Opti-Gen, Encora, Star Wars, Disney Winnie the Pooh Complete, Nutricap, Star Wars Hero Gummies, Disney Winnie the Pooh with Extra C, Nutrivit, Star Wars Villain Gummies, Disney Winnie the Pooh Gummies, Star Wars Yoda Gummies, Mag-SR with Calcium, Folpace Rx, Calafol Rx, Corvite, NIC 750, Tandem Plus, I-Vite Protect, CalciFolic-D, Ostiva, One-A-Day WeightSmart, Ferrocite Plus, Centrum Kids, Ecee Plus, Viactiv Multi-Vitamin Flavor Glides, Biotin Forte with Zinc, Folbee Plus CZ, Antioxidant Ultra Formula, Centrum Ultra Men's, Clusimar, Multi-betic, Centrum Ultra Women's, One-A-Day Women 50 Plus, One-A-Day Men 50 Plus, Thera-M Enhanced, Megavite Rx, Centrum Jr with Extra Calcium, Centrum MultiGummies Women, Recal Fol D)
  • Namenda (memantine)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Anaprox-DS, Naprelan, EC-Naprosyn, Flanax Pain Reliever, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • simvastatin (Zocor, FloLipid)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Larapam SR, Tramedo, Ryzolt, GenRx Tramadol, ConZip, Zydol, Tramal SR, Tramahexal, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Vitamin D3 (cholecalciferol)
  • zolpidem (Ambien, Ambien CR, Zolpimist, Intermezzo, Edluar)

Pain Relief PM Extra Strength (acetaminophen / diphenhydramine) alcohol/food interactions

There is 1 alcohol/food interaction with Pain Relief PM Extra Strength (acetaminophen / diphenhydramine)

Pain Relief PM Extra Strength (acetaminophen / diphenhydramine) disease interactions

There are 11 disease interactions with Pain Relief PM Extra Strength (acetaminophen / diphenhydramine) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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