Skip to Content

Drug interactions between acetaminophen / caffeine / guaifenesin / phenylephrine and amitriptyline

Results for the following 2 drugs:
acetaminophen/caffeine/guaifenesin/phenylephrine
amitriptyline

Interactions between your drugs

Major

amitriptyline phenylephrine

Applies to: amitriptyline and acetaminophen / caffeine / guaifenesin / phenylephrine

Amitriptyline should not be used with phenylephrine except in cases of emergency. If your doctor wants you to take this combination a dosage adjustment may be necessary. Your blood pressure may need to be checked more frequently. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Switch to professional interaction data

Drug and food interactions

Minor

caffeine food

Applies to: acetaminophen / caffeine / guaifenesin / phenylephrine

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

For clinical details see professional interaction data.

Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide