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Fioricet (acetaminophen / butalbital / caffeine) Drug Interactions

Currently displaying 216 drugs known to have a major interaction with Fioricet (acetaminophen / butalbital / caffeine).

Show all medications in the database that may interact with Fioricet (acetaminophen / butalbital / caffeine).

See also: The most common drugs checked in combination with this medicine.

Check for interactions

Type in a drug name to check for interactions with Fioricet (acetaminophen / butalbital / caffeine).

Medications known to interact with Fioricet (acetaminophen / butalbital / caffeine)

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    • epinephrine / prilocaine (Citanest Forte)
    • esketamine (Spravato)
    • ethanol (Alcohol (contained in alcoholic beverages), Ablysinol, Alcohol 5% in Dextrose 5%, Alcohol And Dextrose Injections USP Hypertonic, Palcohol, Dehydrated Alcohol, Ethyl Alcohol)
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    • guaifenesin / hydrocodone (Hydrocod-GF, Narcof, Hycosin Expectorant, Vortex, Condasin, Obredon, Vicodin Tuss, Vicoclear, Vitussin Expectorant, Monte-G HC, CodiCLEAR DH, Maxi-Tuss HCG, EndaCof-Tab, Ztuss ZT, Tusso-HC, Execlear, Hycotuss Expectorant, Pneumotussin HC, Propatuss Expectorant, Kwelcof, Vi-Q-Tuss, Co-Tussin, Codotuss, Fentuss Expectorant, Co-Tuss V Expectorant, Endacof XP, Vicotuss, G-Tuss, Hycoclar Tuss, Cotuss V, Hydrotuss, Gua HC, Hycoclear, Medcodin, Pneumotussin 2.5, Entuss, Pneumotussin, Tusso-DF, Execof, Pancof XP, Touro HC, Xpect-HC, Atuss HX, Extendryl HC, Hydro-Tussin HG, Canges-XP, Z-Cof HCX, Tussicle, A-Cof DH, Relasin-HCX, Flowtuss)
    • guaifenesin / hydrocodone / pheniramine / phenylephrine / phenylpropanolamine (S-T Forte)
    • guaifenesin / hydrocodone / pheniramine / phenylpropanolamine / pyrilamine
    • guaifenesin / hydrocodone / phenylephrine (Mintuss G, Atuss G, Ambi 5/15/100, Tussafed-HC, Levall 5.0, Hydro GP, De-Chlor G, Dynatuss HC, Tussafed-HCG, Uni-Lev 5.0, Crantex HC, Duratuss HD, Simuc-HD, Gentex HC, Donatussin DC, Guiaplex HC, Exetuss-HC, Qual-Tussin DC, Nariz HC, MonteFlu HC, Nazarin HC, HydroFed)
    • guaifenesin / hydrocodone / pseudoephedrine (Hycofenix, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Tussadur-HD, Tussend Expectorant, Detussin Expectorant, Tussgen Expectorant, SRC Expectorant, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, Entuss-D, Hydrotussin HD, KG-Tuss HD, Medtuss HD, Spantuss HD, Vanacon, Su-Tuss HD Elixir, Tussafin Liquid, Hytussin Expectorant, Drituss HD, Hydro-Tuss XP, Dynex HD, Entex HC, Pseudatex HC)
    • guaifenesin / hydromorphone (Dilaudid Cough Syrup)
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    • leflunomide (Arava)
    • levomethadyl acetate (Orlaam)
    • levorphanol (Levo-Dromoran)
    • lidocaine / prilocaine topical (Emla, Medolor Pak, Prilovix, Livixil Pak, Lidopril XR, Emla Anesthetic Disc, Oraqix, Lidopril, Anodyne LPT, Dolotranz, Prikaan, Relador Pak Plus, AgonEaze, Venipuncture CPI, Prilovix Plus, Prilolid, Prilovix Lite, DermacinRx Prizopak, LiproZonePak, DermacinRx Empricaine, DermacinRx Prikaan, Leva Set)
    • lomitapide (Juxtapid)
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    • meperidine (Demerol, Meperitab)
    • meperidine / promethazine (Meprozine, Mepergan, Mepergan Fortis)
    • methadone (Dolophine, Methadose, Methadone Diskets, Methadose Sugar-Free)
    • mipomersen (Kynamro)
    • morphine (MS Contin, Morphine Sulfate ER, Roxanol, Morphine Sulfate IR, Kadian, MorphaBond ER, Duramorph, MSIR, Statex, Arymo ER, Avinza, M-Eslon, Morphine Sulfate SR, Morphine LP Epidural, Oramorph SR, Astramorph PF, Infumorph, Morphine Rapi-Ject, RMS, Mitigo, Duramorph PF, OMS, Roxanol 100, Rescudose, MS/S, Roxanol-T, Doloral, Doloral Sirop, Morphitec, M O S)
    • morphine liposomal (DepoDur)
    • morphine / naltrexone (Embeda)
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    • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Dazidox, Oxyfast, Oxecta, Oxydose, RoxyBond, Percolone, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
    • oxymorphone (Opana, Opana ER, Numorphan HCl, Numorphan)
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    • tapentadol (Nucynta, Nucynta ER)
    • teriflunomide (Aubagio)
    • tizanidine (Zanaflex)
    • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Zydol, Tramahexal, Ryzolt, Tramal SR, ConZip, Larapam SR, GenRx Tramadol, Tramedo, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
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    Fioricet (acetaminophen / butalbital / caffeine) alcohol/food interactions

    There are 6 alcohol/food interactions with Fioricet (acetaminophen / butalbital / caffeine)

    Fioricet (acetaminophen / butalbital / caffeine) disease interactions

    There are 23 disease interactions with Fioricet (acetaminophen / butalbital / caffeine) which include:

    Drug Interaction Classification

    These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
    Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
    Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
    Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
    Unknown No interaction information available.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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