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PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) Drug Interactions

A total of 674 drugs are known to interact with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine).

  • 98 major drug interactions
  • 428 moderate drug interactions
  • 148 minor drug interactions

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Type in a drug name to check for interactions with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine).

Medications known to interact with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine)

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    • edoxaban (Savaysa)
    • efavirenz (Sustiva)
    • efavirenz / emtricitabine / tenofovir (Atripla)
    • efavirenz / lamivudine / tenofovir (Symfi Lo, Symfi)
    • enalapril / felodipine (Lexxel)
    • enalapril / hydrochlorothiazide (Vaseretic)
    • enoxacin (Penetrex)
    • enoxaparin (Lovenox, Clexane, Lovenox HP, Clexane Forte)
    • ephedrine / guaifenesin / theophylline (Primatene Dual Action)
    • ephedrine / hydroxyzine / theophylline (Marax, Hydrophed, Ami-rax, Hydroxy Compound, Marax DF, Theomax DF)
    • ephedrine / phenobarbital / potassium iodide / theophylline (Quadrinal)
    • ephedrine / phenobarbital / theophylline (Tedrigen, Theodrine)
    • epinephrine / prilocaine (Citanest Forte)
    • epirubicin (Ellence, Pharmorubicin PFS, Pharmorubicin RDF)
    • eplerenone (Inspra)
    • epoprostenol (Veletri, Flolan)
    • eprosartan (Teveten)
    • eprosartan / hydrochlorothiazide (Teveten HCT)
    • eptifibatide (Integrilin)
    • escitalopram (Lexapro)
    • esmolol (Brevibloc)
    • esomeprazole (Nexium, Nexium 24HR, Nexium IV)
    • esomeprazole / naproxen (Vimovo)
    • ethacrynic acid (Edecrin, Sodium Edecrin)
    • ethanol (Alcohol (contained in alcoholic beverages), Ablysinol, Dehydrated Alcohol, Ethyl Alcohol, Alcohol 5% in Dextrose 5%, Alcohol And Dextrose Injections USP Hypertonic, Palcohol)
    • ethinyl estradiol (Estinyl)
    • ethinyl estradiol / ethynodiol (Kelnor 1/35, Zovia 1/35E, Demulen 1/35, Demulen, Demulen 1/50, Kelnor 1/50, Lo-Malmorede, Zovia 1/50E, Malmorede)
    • ethinyl estradiol / etonogestrel (NuvaRing)
    • ethinyl estradiol / folic acid / levonorgestrel (FaLessa Kit)
    • ethinyl estradiol / levonorgestrel (Aviane, Alesse, Seasonique, Levora, Seasonale, Lutera, Aubra, Portia, Ashlyna, Orsythia, Vienva, Amethyst, Amethia, Jolessa, Sronyx, Camrese, Daysee, Lessina, Larissia, Altavera, Trivora, Triphasil, Levlen, Lillow, Falmina, Alesse-28, Chateal, Introvale, Kurvelo, LoSeasonique, Quasense, Nordette, Chateal EQ, Lybrel, Setlakin, Simpesse, Balcoltra, Amethia Lo, Enpresse, Rivelsa, Levonest, Jaimiess, Nordette-21, Alesse-21, Levlite, Preven EC, Myzilra, Delyla, Aubra EQ, Marlissa, Quartette, Ayuna, Lo Simpesse, Fayosim, Cerinta, Afirmelle, Elifemme, Nordette-28, Tri-Levlen, Triphasil-21, Triphasil-28, Sylevia, Triquilar 21, Triquilar 28, Min-Ovral 21, Min-Ovral 28, CamreseLo, Iclevia)
    • ethinyl estradiol / norelgestromin (Xulane, Ortho Evra)
    • ethinyl estradiol / norethindrone (Lo Loestrin Fe, Junel Fe 1/20, Taytulla, Necon 1/35, Microgestin Fe 1/20, Loestrin Fe 1/20, Blisovi 24 Fe, Estrostep Fe, Nortrel 1/35, Minastrin 24 Fe, Junel 1.5/30, Junel Fe 1.5/30, Blisovi Fe 1.5/30, Loestrin 21 1/20, Mibelas 24 Fe, Loestrin Fe 1.5/30, Junel 1/20, Blisovi Fe 1/20, Junel Fe 24, Tarina Fe 1/20, Microgestin 1.5/30, Loestrin 24 Fe, femhrt, Layolis Fe, Cyclafem 1/35, Jinteli, Microgestin 1/20, Balziva, Melodetta 24 Fe, Wymzya Fe, Ortho-Novum 1/35, Necon 0.5/35, Necon 10/11, Microgestin Fe 1.5/30, Necon 7/7/7, Femcon Fe, Kaitlib Fe, Alyacen 1/35, Larin Fe 1.5/30, Brevicon, Norinyl 1+35, Loestrin 21 1.5/30, Ovcon 50, Nortrel 7/7/7, Leena, Tri-Legest, Tri-Legest Fe, Larin Fe 1/20, Generess Fe, Larin 24 Fe, Jevantique, Hailey 24 Fe, Wera, Pirmella 7/7/7, Pirmella 1/35, Ovcon 35, Ortho-Novum 7/7/7, Tri-Norinyl, Jenest, Ortho-Novum 10/11, Aranelle, Zenchent Fe, Nortrel 0.5/35, Zenchent, Aurovela Fe 1.5/30, Aurovela Fe 1/20, Tarina 24 Fe, Fyavolv, Tilia Fe, Briellyn, Dasetta, Alyacen 7/7/7, Gildess 1/20, Vyfemla, Gildess 24 Fe, Hailey Fe 1/20, Modicon, Cyclafem 7/7/7, Genora 0.5/35, Nelova 0.5/35, Gildess Fe 1.5/30, Gildess Fe 1/20, Genora 1/35, Norethin 1/35 E, Nelova 10/11, Nelova 1/35, Ovcon 35 Fe, Nylia 7/7/7, Cyonanz, Nylia 1/35, Aurovela 24 Fe, Aurovela 1/20, Leribane, Aurovela 1.5/30, Cyclafem 0.5/35, Lo Minastrin Fe, Gildagia, Lomedia 24 Fe, Dasetta 7/7/7, Philith, Dasetta 1/35, Zeosa, Hailey 1.5/30, Hailey Fe 1.5/30, Nexesta Fe, Gildess 1.5/30, Microgestin 24 Fe, Larin 1.5/30, Larin 1/20, Jevantique Lo)
    • ethinyl estradiol / norgestimate (Sprintec, Ortho Tri-Cyclen, Tri-Sprintec, TriNessa, Ortho Tri-Cyclen Lo, Estarylla, Ortho Cyclen, Mononessa, Mono-Linyah, Tri-Lo-Sprintec, Femynor, TriNessa Lo, Tri-Lo-Marzia, Previfem, Tri-Lo-Estarylla, VyLibra, Tri-Linyah, Mili, Tri-Previfem, Tri Femynor, Tri-Estarylla, Tri-VyLibra, Tri-Vylibra Lo, Tri-Lo-Mili, Tri-Mili)
    • ethinyl estradiol / norgestrel (Cryselle, Low-Ogestrel-28, Lo/Ovral, Ovral, Elinest, Ogestrel 0.5/50, Lo/Ovral-28, Ovral-28, Ovral-21)
    • ethinyl estradiol / segesterone (Annovera)
    • ethotoin (Peganone)
    • etidronate (Didronel, Didronel IV)
    • etodolac (Lodine, Lodine XL)
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    • nabumetone (Relafen)
    • nadolol (Corgard)
    • nalidixic acid (NegGram)
    • naltrexone (Vivitrol, Revia, Depade)
    • naltrexone / oxycodone (Troxyca ER)
    • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
    • naproxen / pseudoephedrine (Aleve-D Sinus & Cold, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain, Aleve-D Sinus & Headache)
    • naproxen / sumatriptan (Treximet)
    • nateglinide (Starlix)
    • nebivolol (Bystolic)
    • nebivolol / valsartan (Byvalson)
    • nepafenac ophthalmic (Ilevro, Nevanac)
    • netilmicin (Netromycin)
    • niacin (Niaspan, Nicotinic Acid, Niacin SR, Slo-Niacin, Niacor, Nicobid Tempules, Nicotinex, B-3-50, B3-500-Gr, Niacor B3, Nico-400, HDL Benefit, Nicolar)
    • niacin / simvastatin (Simcor)
    • nicardipine (Cardene, Cardene IV, Cardene SR)
    • nicotine (Nicoderm CQ, Nicorette, Habitrol, Nicotrol Inhaler, Leader Nicotine Polacrilex, Nicotrol NS, Commit, Nicorelief, ProStep, Nicorette DS, Nicotrol TD)
    • nifedipine (Procardia, Adalat, Nifedical XL, Procardia XL, Nifediac CC, Adalat CC, Afeditab CR)
    • nimodipine (Nimotop, Nymalize)
    • nintedanib (Ofev)
    • nisoldipine (Sular)
    • nitroglycerin (Nitrostat, NitroQuick, Nitro-Bid, Nitro-Dur, Nitrolingual Pumpspray, Tridil, Rectiv, Minitran, Nitroglyn E-R, Nitro TD Patch-A, Nitrogard, Nitrostat Tablets, Nitrol, Nitro-Time, Deponit, Nitrodisc, Nitro-Par, Nitrocot, Nitro-Bid IV, Nitrong, Nitrol Appli-Kit, Nitrek, NitroMist, GoNitro, Transderm-Nitro)
    • norfloxacin (Noroxin)
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    • obeticholic acid (Ocaliva)
    • ofloxacin (Floxin, Floxin IV)
    • olaparib (Lynparza)
    • olmesartan (Benicar)
    • omacetaxine (Synribo)
    • omega-3 polyunsaturated fatty acids (Fish Oil, Lovaza, Omega-3, Omega 3-6-9 Complex, Omega-500, Nature's Bounty Red Krill Oil, Vayarin, MegaKrill, Omacor, Prenatal DHA, Fish Oil Ultra, MaxEPA, Epanova, Marine Lipid Concentrate, Vascazen, Dry Eye Omega Benefits, Sundown Naturals Triple Strength Red Krill Oil, Systane Vitamin Omega-3 Healthy Tears, MaxiTears Dry Eye Formula, Sea-Omega, Super-EPA, Proepa, EPA Fish Oil, Icar Prenatal Essential Omega-3, Sea-Omega 30, Sea-Omega 70, Animi-3, Mi-Omega NF, Omega Essentials, Omega Essentials Basic, Mi-Omega, TheraTears Nutrition, Wellbaby DHA, Divista, Ovega-3 Vegetarian, MaxiVision Omega-3 Formula, Animi-3 with Vitamin D, TherOmega, Omtryg, Cardio Omega Benefits, Flex Omega Benefits, Triklo, Mom's Omega Advantage, TherOmega Sport, Dialyvite Omega-3 Concentrate, Maximum Red Krill)
    • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
    • omeprazole / sodium bicarbonate (Zegerid, Zegerid OTC)
    • osimertinib (Tagrisso)
    • ospemifene (Osphena)
    • oxaprozin (Daypro, Daypro Alta)
    • oxazepam (Serax)
    • oxybutynin (Ditropan, Ditropan XL, Oxytrol, Gelnique, Oxytrol for Women, Urotrol, Anturol)
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    • quinapril (Accupril)
    • quinidine (Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Cardioquin, Quin-Release, Quin-G)
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    PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) alcohol/food interactions

    There are 6 alcohol/food interactions with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine)

    PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) disease interactions

    There are 21 disease interactions with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) which include:

    Drug Interaction Classification

    These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
    Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
    Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
    Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
    Unknown No interaction information available.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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