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PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) Drug Interactions

A total of 671 drugs are known to interact with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine).

  • 97 major drug interactions
  • 426 moderate drug interactions
  • 148 minor drug interactions

Check for interactions with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine)

Type in a drug name and select a drug from the list.

Medications known to interact with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine)

A B C D E F G H I K L M N O P Q R S T U V W Z

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  • edoxaban (Savaysa)
  • efavirenz (Sustiva)
  • efavirenz / emtricitabine / tenofovir (Atripla)
  • efavirenz / lamivudine / tenofovir (Symfi, Symfi Lo)
  • enalapril / felodipine (Lexxel)
  • enalapril / hydrochlorothiazide (Vaseretic)
  • enoxacin (Penetrex)
  • enoxaparin (Lovenox, Clexane, Lovenox HP, Clexane Forte)
  • ephedrine / guaifenesin / theophylline (Primatene Dual Action)
  • ephedrine / hydroxyzine / theophylline (Marax, Hydrophed, Ami-rax, Hydroxy Compound, Marax DF, Theomax DF)
  • ephedrine / phenobarbital / potassium iodide / theophylline (Quadrinal)
  • ephedrine / phenobarbital / theophylline (Tedrigen, Theodrine)
  • epinephrine / prilocaine (Citanest Forte)
  • epirubicin (Ellence, Pharmorubicin PFS, Pharmorubicin RDF)
  • eplerenone (Inspra)
  • epoprostenol (Veletri, Flolan)
  • eprosartan (Teveten)
  • eprosartan / hydrochlorothiazide (Teveten HCT)
  • eptifibatide (Integrilin)
  • escitalopram (Lexapro)
  • esmolol (Brevibloc)
  • esomeprazole (Nexium, Nexium 24HR, Nexium IV)
  • esomeprazole / naproxen (Vimovo)
  • ethacrynic acid (Edecrin, Sodium Edecrin)
  • ethanol (Alcohol (contained in alcoholic beverages), Ethyl Alcohol, Alcohol 5% in Dextrose 5%, Alcohol And Dextrose Injections USP Hypertonic, Palcohol, Dehydrated Alcohol, Ablysinol)
  • ethinyl estradiol (Estinyl)
  • ethinyl estradiol / ethynodiol (Kelnor 1/35, Zovia 1/35E, Demulen, Demulen 1/35, Demulen 1/50, Kelnor 1/50, Zovia 1/50E, Malmorede)
  • ethinyl estradiol / etonogestrel (NuvaRing)
  • ethinyl estradiol / folic acid / levonorgestrel (FaLessa Kit)
  • ethinyl estradiol / levonorgestrel (Aviane, Alesse, Lutera, Levora, Seasonique, Portia, Aubra, Camrese, Vienva, Lessina, Levlen, Ashlyna, Jolessa, Altavera, Kurvelo, Larissia, Lillow, Falmina, Seasonale, Trivora, Sronyx, Chateal, Amethia, Levlite, Marlissa, Amethyst, Introvale, Fayosim, Alesse-28, Orsythia, Lybrel, Quartette, Daysee, Balcoltra, Amethia Lo, Quasense, CamreseLo, Ayuna, Levonest, Nordette, Triphasil, LoSeasonique, Nordette-21, Nordette-28, Enpresse, Myzilra, Setlakin, Rivelsa, Simpesse, Lo Simpesse, Jaimiess, Afirmelle, Elifemme, Tri-Levlen, Triphasil-21, Triphasil-28, Alesse-21, Preven EC, Triquilar 21, Triquilar 28, Min-Ovral 21, Min-Ovral 28, Delyla, Iclevia, Aubra EQ, Chateal EQ)
  • ethinyl estradiol / norelgestromin (Xulane, Ortho Evra)
  • ethinyl estradiol / norethindrone (Lo Loestrin Fe, Taytulla, Junel Fe 1/20, Loestrin 24 Fe, Microgestin Fe 1/20, Minastrin 24 Fe, Necon 1/35, Junel Fe 1.5/30, Jinteli, Loestrin Fe 1.5/30, Blisovi Fe 1/20, Mibelas 24 Fe, Loestrin 21 1/20, Blisovi Fe 1.5/30, Cyclafem 1/35, Estrostep Fe, Microgestin 1.5/30, Junel Fe 24, Microgestin 1/20, Balziva, Blisovi 24 Fe, Loestrin Fe 1/20, femhrt, Necon 0.5/35, Nortrel 1/35, Dasetta 1/35, Alyacen 1/35, Larin Fe 1/20, Ortho-Novum 7/7/7, Microgestin Fe 1.5/30, Fyavolv, Dasetta, Larin Fe 1.5/30, Melodetta 24 Fe, Generess Fe, Brevicon, Gildess Fe 1/20, Ortho-Novum 1/35, Aranelle, Junel 1.5/30, Nortrel 0.5/35, Gildagia, Tilia Fe, Philith, Vyfemla, Larin 24 Fe, Wera, Wymzya Fe, Modicon, Cyclafem 7/7/7, Ovcon 35, Gildess Fe 1.5/30, Norinyl 1+35, Norethin 1/35 E, Tarina Fe 1/20, Jenest, Nortrel 7/7/7, Leena, Junel 1/20, Zenchent, Lo Minastrin Fe, Tri-Legest Fe, Lomedia 24 Fe, Dasetta 7/7/7, Zeosa, Hailey 1.5/30, Alyacen 7/7/7, Microgestin 24 Fe, Larin 1.5/30, Layolis Fe, Gildess 24 Fe, Jevantique, Hailey Fe 1/20, Hailey 24 Fe, Pirmella 7/7/7, Pirmella 1/35, Genora 0.5/35, Nelova 0.5/35, Genora 1/35, Loestrin 21 1.5/30, Nelova 10/11, Nelova 1/35, Necon 10/11, Tri-Norinyl, Ovcon 50, Ortho-Novum 10/11, Necon 7/7/7, Zenchent Fe, Ovcon 35 Fe, Femcon Fe, Nylia 7/7/7, Cyonanz, Nylia 1/35, Aurovela Fe 1.5/30, Aurovela 24 Fe, Aurovela Fe 1/20, Aurovela 1/20, Leribane, Aurovela 1.5/30, Cyclafem 0.5/35, Kaitlib Fe, Tri-Legest, Briellyn, Hailey Fe 1.5/30, Nexesta Fe, Gildess 1.5/30, Gildess 1/20, Larin 1/20, Jevantique Lo)
  • ethinyl estradiol / norgestimate (Sprintec, Ortho Tri-Cyclen, TriNessa, Tri-Sprintec, Mononessa, Estarylla, Ortho Cyclen, Mono-Linyah, Femynor, Previfem, Ortho Tri-Cyclen Lo, TriNessa Lo, Tri-Linyah, Tri-Lo-Marzia, Tri-Lo-Sprintec, Tri-Lo-Estarylla, Mili, Tri-VyLibra, VyLibra, Tri Femynor, Tri-Estarylla, Tri-Previfem, Tri-Lo-Mili, Tri-Mili)
  • ethinyl estradiol / norgestrel (Cryselle, Lo/Ovral, Ovral, Elinest, Lo/Ovral-28, Low-Ogestrel-28, Ovral-21, Ovral-28, Ogestrel 0.5/50)
  • ethinyl estradiol / segesterone (Annovera)
  • ethotoin (Peganone)
  • etidronate (Didronel, Didronel IV)
  • etodolac (Lodine, Lodine XL)
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K
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M
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  • nabumetone (Relafen)
  • nadolol (Corgard)
  • nalidixic acid (NegGram)
  • naltrexone (Vivitrol, Revia, Depade)
  • naltrexone / oxycodone (Troxyca ER)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, Flanax Pain Reliever, Leader Naproxen Sodium, EC-Naprosyn, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • naproxen / pseudoephedrine (Aleve-D Sinus & Cold, Aleve-D Sinus & Headache, Sinus & Cold D, Sudafed 12 Hour Pressure+Pain)
  • naproxen / sumatriptan (Treximet)
  • nateglinide (Starlix)
  • nebivolol (Bystolic)
  • nebivolol / valsartan (Byvalson)
  • nepafenac ophthalmic (Ilevro, Nevanac)
  • netilmicin (Netromycin)
  • niacin (Niaspan, Niacor, Niacin SR, Nicotinic Acid, Slo-Niacin, Nicotinex, Nicobid Tempules, B-3-50, B3-500-Gr, Niacor B3, Nico-400, HDL Benefit, Nicolar)
  • niacin / simvastatin (Simcor)
  • nicardipine (Cardene, Cardene IV, Cardene SR)
  • nicotine (Nicoderm CQ, Nicorette, Nicotrol Inhaler, Habitrol, Leader Nicotine Polacrilex, Nicotrol NS, Commit, Nicorelief, ProStep, Nicorette DS, Nicotrol TD)
  • nifedipine (Procardia, Nifedical XL, Adalat, Procardia XL, Nifediac CC, Afeditab CR, Adalat CC)
  • nimodipine (Nimotop, Nymalize)
  • nintedanib (Ofev)
  • nisoldipine (Sular)
  • nitroglycerin (Nitrostat, NitroQuick, Nitro-Dur, Nitrolingual Pumpspray, Nitro-Bid, Nitroglyn E-R, Minitran, Tridil, Rectiv, Nitrogard, NitroMist, Nitrostat Tablets, Nitrol, Transderm-Nitro, Nitro TD Patch-A, GoNitro, Deponit, Nitrodisc, Nitro-Par, Nitrocot, Nitro-Bid IV, Nitrong, Nitrol Appli-Kit, Nitrek, Nitro-Time)
  • norfloxacin (Noroxin)
O
  • obeticholic acid (Ocaliva)
  • ofloxacin (Floxin, Floxin IV)
  • olaparib (Lynparza)
  • olmesartan (Benicar)
  • omacetaxine (Synribo)
  • omega-3 polyunsaturated fatty acids (Fish Oil, Lovaza, Omega-3, Omega-500, Omega 3-6-9 Complex, Vayarin, Nature's Bounty Red Krill Oil, Omacor, EPA Fish Oil, Epanova, MaxiTears Dry Eye Formula, Prenatal DHA, MegaKrill, Sea-Omega 30, Fish Oil Ultra, TheraTears Nutrition, MaxiVision Omega-3 Formula, Cardio Omega Benefits, Flex Omega Benefits, Mom's Omega Advantage, Systane Vitamin Omega-3 Healthy Tears, Sea-Omega, Marine Lipid Concentrate, Super-EPA, MaxEPA, Proepa, Icar Prenatal Essential Omega-3, Sea-Omega 70, Animi-3, Mi-Omega NF, Omega Essentials, Omega Essentials Basic, Mi-Omega, Vascazen, Wellbaby DHA, Divista, Ovega-3 Vegetarian, Animi-3 with Vitamin D, TherOmega, Omtryg, Dry Eye Omega Benefits, Sundown Naturals Triple Strength Red Krill Oil, Triklo, TherOmega Sport, Dialyvite Omega-3 Concentrate, Maximum Red Krill)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • omeprazole / sodium bicarbonate (Zegerid, Zegerid OTC)
  • osimertinib (Tagrisso)
  • ospemifene (Osphena)
  • oxaprozin (Daypro, Daypro Alta)
  • oxazepam (Serax)
  • oxybutynin (Ditropan, Ditropan XL, Oxytrol, Anturol, Gelnique, Urotrol, Oxytrol for Women)
P
Q
  • quinapril (Accupril)
  • quinidine (Quinora, Quinidex Extentabs, Cardioquin, Quinaglute Dura-Tabs, Quin-Release, Quin-G)
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PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) alcohol/food interactions

There are 6 alcohol/food interactions with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine)

PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) disease interactions

There are 21 disease interactions with PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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