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Drug interactions between ACAM2000 and methylprednisolone

Results for the following 2 drugs:
ACAM2000 (smallpox vaccine)
methylprednisolone

Interactions between your drugs

Major

methylPREDNISolone smallpox vaccine

Applies to: methylprednisolone and ACAM2000 (smallpox vaccine)

If you are currently being treated or have recently been treated with a steroid such as methylPREDNISolone, you should talk to your doctor before receiving smallpox vaccine. Depending on the dose and length of time you have been on the steroid, you may be at risk for developing an infection or other side effects from the vaccine, or have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of methylPREDNISolone therapy. If you have recently been vaccinated with smallpox vaccine, your doctor may choose to postpone treatment with methylPREDNISolone for a couple of weeks. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

methylPREDNISolone food

Applies to: methylprednisolone

Grapefruit juice may increase the blood levels of certain medications such as methylPREDNISolone. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with methylPREDNISolone. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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