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Drug interactions between ACAM2000 and deflazacort

Results for the following 2 drugs:
ACAM2000 (smallpox vaccine)
deflazacort

Interactions between your drugs

Major

smallpox vaccine deflazacort

Applies to: ACAM2000 (smallpox vaccine) and deflazacort

If you are currently being treated or have recently been treated with a steroid such as deflazacort, you should talk to your doctor before receiving smallpox vaccine. Depending on the dose and length of time you have been on the steroid, you may be at risk for developing an infection or other side effects from the vaccine, or have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of deflazacort therapy. If you have recently been vaccinated with smallpox vaccine, your doctor may choose to postpone treatment with deflazacort for a couple of weeks. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

deflazacort food

Applies to: deflazacort

Do not take deflazacort with grapefruit juice. Grapefruit juice may increase the blood levels of the active component of deflazacort. This may increase the risk and/or severity of side effects such as swelling, weight gain, electrolyte abnormalities, high blood pressure, high blood glucose, muscle weakness, depression, mood swings, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, glaucoma, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. Children may experience a reduced growth rate during chronic use. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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