Drug Interactions between acalabrutinib and Ascomp with Codeine

This report displays the potential drug interactions for the following 2 drugs:

acalabrutinib
Ascomp with Codeine (aspirin/butalbital/caffeine/codeine)

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Consumer
Professional

Interactions between your drugs

Major

codeine butalbital

Applies to: Ascomp with Codeine (aspirin / butalbital / caffeine / codeine) and Ascomp with Codeine (aspirin / butalbital / caffeine / codeine)

Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including profound sedation, respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Do not drink alcohol or self-medicate with these medications without your doctor's approval, and do not exceed the doses or frequency and duration of use prescribed by your doctor. Also, because these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed and motor coordination, you should avoid driving or operating hazardous machinery until you know how they affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Major

aspirin acalabrutinib

Applies to: Ascomp with Codeine (aspirin / butalbital / caffeine / codeine) and acalabrutinib

Using acalabrutinib together with aspirin may increase the risk of bleeding. In clinical studies, treatment with acalabrutinib alone has been associated with severe and sometimes fatal hemorrhage. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions such as monitoring you closely for any potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; a severe headache; and/or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate

butalbital acalabrutinib

Applies to: Ascomp with Codeine (aspirin / butalbital / caffeine / codeine) and acalabrutinib

Butalbital may reduce the blood levels of acalabrutinib, which may make the medication less effective in some cases. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor

aspirin caffeine

Applies to: Ascomp with Codeine (aspirin / butalbital / caffeine / codeine) and Ascomp with Codeine (aspirin / butalbital / caffeine / codeine)

Information for this minor interaction is available on the professional version.

Drug and food interactions

Major

acalabrutinib food

Applies to: acalabrutinib

Acalabrutinib may be taken with or without food. However, consumption of grapefruit and grapefruit juice can increase the blood levels of acalabrutinib. This may increase side effects such as nausea, vomiting, diarrhea, abdominal pain, hemorrhage, development of other cancers, abnormal heart rhythm, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. You should avoid the consumption of grapefruit and grapefruit juice during treatment with acalabrutinib. Be sure to take the medication at approximately the same time(s) every day to maintain consistent blood levels and effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Major