Drug Interactions between abiraterone and All Day Pain Relief
This report displays the potential drug interactions for the following 2 drugs:
- abiraterone
- All Day Pain Relief (naproxen)
Interactions between your drugs
naproxen abiraterone
Applies to: All Day Pain Relief (naproxen) and abiraterone
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with abiraterone acetate may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 2C8. Abiraterone is a potent inhibitor of CYP450 2C8 in vitro. In a drug interaction study with healthy subjects, administration of the CYP450 2C8 substrate pioglitazone with a single 1000 mg dose of abiraterone acetate resulted in a 46% increase in pioglitazone systemic exposure (AUC).
MANAGEMENT: Caution is advised if abiraterone acetate is prescribed with medications that undergo metabolism by CYP450 2C8, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever abiraterone acetate is added to or withdrawn from therapy.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Canadian Pharmacists Association "e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink" (2006):
- "Product Information. Zytiga (abiraterone)." Centocor Inc (2011):
- "Product Information. Akeega (abiraterone-niraparib)." Janssen Biotech, Inc. (2023):
- "Product Information. Akeega (abiraterone-niraparib)." Janssen Inc (2023):
- "Product Information. Zytiga (abiraterone)." Janssen Biotech, Inc. (2021):
- "Product Information. Yonsa (abiraterone)." Sun Pharmaceutical Industries (2022):
- "Product Information. Apo-Abiraterone (abiraterone)." Apotex Inc (2023):
- "Product Information. Zytiga (abiraterone)." Janssen-Cilag Pty Ltd (2021):
- "Product Information. Abiraterone (abiraterone)." Wockhardt UK Ltd (2023):
Drug and food interactions
abiraterone food
Applies to: abiraterone
Taking abiraterone with food increases the amount of medicine that gets absorbed by the body. This may increase the risk of side effects such as high blood pressure, water retention, and a condition called hypokalemia (low blood potassium), which in severe cases can lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. You should take abiraterone once a day on an empty stomach. No food should be eaten for at least two hours before and one hour after taking abiraterone. Let your doctor know if you experience nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness or tingling, rapid heart beat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia or excessive effects of abiraterone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
naproxen food
Applies to: All Day Pain Relief (naproxen)
Ask your doctor before using naproxen together with ethanol. Do not drink alcohol while taking naproxen. Alcohol can increase your risk of stomach bleeding caused by naproxen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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