Difelikefalin Interactions
Showing entire list of all interactions, including brand names and combination drugs.
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Medications known to interact with difelikefalin
P
- P Chlor DM (chlorpheniramine / dextromethorphan / phenylephrine)
- P Chlor GG (chlorpheniramine / guaifenesin / phenylephrine)
- P-Hist (dexchlorpheniramine / dextromethorphan / phenylephrine / pyrilamine)
- P-Hist DM Drops (brompheniramine / dextromethorphan / pseudoephedrine)
- P-Tann (chlorpheniramine)
- P-Tann D (chlorpheniramine / phenylephrine)
- P-Tex (brompheniramine)
- P-Tuss DM (dextromethorphan / guaifenesin / pseudoephedrine)
- P-V-Tussin (hydrocodone / pseudoephedrine)
- P-V-Tussin Syrup (chlorpheniramine / hydrocodone / pseudoephedrine)
- Pacaps (acetaminophen / butalbital / caffeine)
- Pain Relief PM Extra Strength (acetaminophen / diphenhydramine)
- Pain Reliever PM (acetaminophen / diphenhydramine)
- Palcohol (ethanol)
- Palgic (carbinoxamine)
- Palgic DS (carbinoxamine / pseudoephedrine)
- Palgic-D (carbinoxamine / pseudoephedrine)
- Palgic-DC (carbinoxamine / pseudoephedrine)
- paliperidone
- Palladone (hydromorphone)
- Pamelor (nortriptyline)
- Pamprin Maximum Pain (acetaminophen / pamabrom / pyrilamine)
- Pamprin Multi-Symptom Menstrual Relief (acetaminophen / pamabrom / pyrilamine)
- Panacet (acetaminophen / hydrocodone)
- Panasal 5 / 500 (aspirin / hydrocodone)
- Panatuss DXP (dexbrompheniramine / dextromethorphan / phenylephrine)
- Panatuss PED (chlophedianol / dexchlorpheniramine / pseudoephedrine)
- Panatuss PED Drops (chlophedianol / dexchlorpheniramine / pseudoephedrine)
- Panatuss Pediatric DXP (dexbrompheniramine / dextromethorphan / phenylephrine)
- Pancof (chlorpheniramine / dihydrocodeine / pseudoephedrine)
- Pancof EXP (dihydrocodeine / guaifenesin / pseudoephedrine)
- Pancof HC (hydrocodone / pseudoephedrine)
- Pancof XP (guaifenesin / hydrocodone)
- Pancof-PD (chlorpheniramine / dihydrocodeine / phenylephrine)
- Panlor (acetaminophen / caffeine / dihydrocodeine)
- Panlor DC (acetaminophen / caffeine / dihydrocodeine)
- Panlor SS (acetaminophen / caffeine / dihydrocodeine)
- PanMist DM (dextromethorphan / guaifenesin / pseudoephedrine)
- Pannaz (carbinoxamine / methscopolamine / pseudoephedrine)
- Pannaz S (carbinoxamine / methscopolamine / pseudoephedrine)
- Paradione (paramethadione)
- Paraflex (chlorzoxazone)
- Parafon Forte DSC (chlorzoxazone)
- Paral (paraldehyde)
- paraldehyde
- paramethadione
- Parcopa (carbidopa / levodopa)
- Pardryl (diphenhydramine)
- Paregoric (opium)
- Parlodel (bromocriptine)
- Parnate (tranylcypromine)
- paroxetine
- Patanase (olopatadine nasal)
- Paxarel (acetylcarbromal)
- Paxil (paroxetine)
- Paxil CR (paroxetine)
- Paxipam (halazepam)
- PB-Hyos (atropine / hyoscyamine / phenobarbital / scopolamine)
- PBM Allergy (brompheniramine / dextromethorphan / pseudoephedrine)
- PBZ (tripelennamine)
- PBZ-SR (tripelennamine)
- PC-CAP (aspirin / caffeine / propoxyphene)
- PCM (chlorpheniramine / methscopolamine / phenylephrine)
- PCM Allergy (chlorpheniramine / methscopolamine / phenylephrine)
- PCM-LA (chlorpheniramine / methscopolamine / pseudoephedrine)
- PD-Cof (chlorpheniramine / dextromethorphan / phenylephrine)
- PD-Cof Drops (chlorpheniramine / dextromethorphan / phenylephrine)
- PD-Hist D (chlorpheniramine / phenylephrine)
- PD-Hist D Drops (chlorpheniramine / phenylephrine)
- PDM GG (dextromethorphan / guaifenesin / phenylephrine)
- PE-Hist DM (chlorpheniramine / dextromethorphan / phenylephrine)
- Pecgen DMX (dextromethorphan / guaifenesin)
- Pedia Relief (dextromethorphan)
- Pedia Relief Cough-Cold (chlorpheniramine / dextromethorphan / pseudoephedrine)
- Pedia Relief Infant (dextromethorphan / pseudoephedrine)
- PediaCare Children's 24-Hour Allergy (cetirizine)
- PediaCare Children's Allergy (diphenhydramine)
- PediaCare Children's Allergy & Cold (diphenhydramine / phenylephrine)
- PediaCare Children's Long-Acting Cough (dextromethorphan)
- PediaCare Children's Multi-Symptom Cold (dextromethorphan / phenylephrine)
- PediaCare Cough & Congestion (dextromethorphan / guaifenesin)
- PediaCare Cough & Runny Nose Plus Acetaminophen (acetaminophen / chlorpheniramine / dextromethorphan)
- PediaCare Cough & Sore Throat Plus Acetaminophen (acetaminophen / dextromethorphan)
- PediaCare Daytime Multi-Symptom Cold (dextromethorphan / phenylephrine)
- PediaCare Flu Plus Acetaminophen (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)
- PediaCare Multi-Symptom Cold Plus Acetaminophen (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)
- PediaCare Nighttime Multi-Symptom Cold (diphenhydramine / phenylephrine)
- PediaClear 8 (pyrilamine)
- Pediacof (chlorpheniramine / codeine / phenylephrine / potassium iodide)
- Pediacon DX (dextromethorphan / guaifenesin / phenylpropanolamine)
- PediaHist DM (brompheniramine / dextromethorphan / pseudoephedrine)
- Pediahist DM Drops (brompheniramine / dextromethorphan / pseudoephedrine)
- Pediahist DM Syrup (brompheniramine / dextromethorphan / guaifenesin / pseudoephedrine)
- PediaTan (chlorpheniramine)
- PediaTan D (chlorpheniramine / phenylephrine)
- Pediatex (carbinoxamine)
- Pediatex 12 (carbinoxamine)
- Pediatex 12 DM (carbinoxamine / dextromethorphan / pseudoephedrine)
- Pediatex 12D (carbinoxamine / pseudoephedrine)
- Pediatex HC (chlorpheniramine / hydrocodone / pseudoephedrine)
- Pediatex TD (pseudoephedrine / triprolidine)
- Pediatex-CT (diphenhydramine / phenylephrine)
- Pediatex-D (carbinoxamine / pseudoephedrine)
- Pediatex-DM (carbinoxamine / dextromethorphan / pseudoephedrine)
- Pediox (carbinoxamine)
- Pediox Chewable (chlorpheniramine / pseudoephedrine)
- Pedituss (chlorpheniramine / codeine / phenylephrine / potassium iodide)
- Peganone (ethotoin)
- pentazocine
- pentobarbital
- Pentothal (thiopental)
- Pepto PM Gummies (calcium phosphate, tribasic / melatonin)
- perampanel
- Percocet (acetaminophen / oxycodone)
- Percocet 10 / 325 (acetaminophen / oxycodone)
- Percocet 10 / 650 (acetaminophen / oxycodone)
- Percocet 2.5 / 325 (acetaminophen / oxycodone)
- Percocet 5 / 325 (acetaminophen / oxycodone)
- Percocet 7.5 / 325 (acetaminophen / oxycodone)
- Percocet 7.5 / 500 (acetaminophen / oxycodone)
- Percodan (aspirin / oxycodone)
- Percodan-Demi (aspirin / oxycodone)
- Percogesic Extra Strength (acetaminophen / diphenhydramine)
- Percogesic Original Strength (acetaminophen / diphenhydramine)
- Percolone (oxycodone)
- pergolide
- Periactin (cyproheptadine)
- Perloxx (acetaminophen / oxycodone)
- Permax (pergolide)
- Permitil (fluphenazine)
- perphenazine
- Perseris (risperidone)
- Pertussin CS Childrens (dextromethorphan)
- Pertussin DM (dextromethorphan)
- Pertussin ES (dextromethorphan)
- Pexeva (paroxetine)
- Phanatuss (dextromethorphan / guaifenesin)
- Pharbechlor (chlorpheniramine)
- Pharbedryl (diphenhydramine)
- Pharbetol PM (acetaminophen / diphenhydramine)
- Pharmadrine (dexbrompheniramine / pseudoephedrine)
- Pharmagesic (acetaminophen / butalbital / caffeine)
- Phena-Plus (chlorpheniramine / phenylephrine / pyrilamine)
- Phena-S (chlorpheniramine / phenylephrine / pyrilamine)
- Phena-S 12 (chlorpheniramine / phenylephrine / pyrilamine)
- Phenabid DM (chlorpheniramine / dextromethorphan / phenylephrine)
- phenacemide
- Phenadex (dextromethorphan / guaifenesin / phenylpropanolamine)
- Phenadoz (promethazine)
- Phenagesic (acetaminophen / phenyltoloxamine)
- Phenagil (chlorpheniramine / phenylephrine)
- Phenagil CH (chlophedianol / chlorpheniramine / phenylephrine)
- Phenaphen with Codeine (acetaminophen / codeine)
- Phenaz Plus (butabarbital / hyoscyamine / phenazopyridine)
- Phenazine 50 (promethazine)
- PhenazoForte Plus (butabarbital / hyoscyamine / phenazopyridine)
- Phencarb GG (carbetapentane / guaifenesin / phenylephrine)
- Phenchlor Tannate Pediatric (chlorpheniramine / phenylephrine)
- PhendaCof Plus (hydrocodone / phenylephrine / pyrilamine)
- Phendal-HD (chlorpheniramine / hydrocodone / phenylephrine)
- phenelzine
- Phenergan (promethazine)
- Phenergan Fortis (promethazine)
- Phenergan VC (phenylephrine / promethazine)
- Phenergan VC with Codeine (codeine / phenylephrine / promethazine)
- Phenergan with Dextromethorphan (dextromethorphan / promethazine)
- Phenflu CD (acetaminophen / codeine / guaifenesin / phenylephrine)
- Phenflu CDX (acetaminophen / codeine / guaifenesin / phenylephrine)
- Phenflu DM (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
- Phenhist Expectorant (codeine / guaifenesin / pseudoephedrine)
- phenindamine
- pheniramine / phenylephrine
- pheniramine / phenylpropanolamine / phenyltoloxamine / pyrilamine
- pheniramine / phenylpropanolamine / pyrilamine
- pheniramine / phenyltoloxamine / pseudoephedrine / pyrilamine
- pheniramine / phenyltoloxamine / pyrilamine
- phenobarbital
- Phenohytro (atropine / hyoscyamine / phenobarbital / scopolamine)
- Phenoject-50 (promethazine)
- phensuximide
- phentermine / topiramate
- Phenurone (phenacemide)
- Phenyl 15 / 12mg (brompheniramine / phenylephrine)
- Phenyl 7.5 / 6mg (brompheniramine / phenylephrine)
- Phenylephrine HD (hydrocodone / phenylephrine)
- phenylephrine / promethazine
- phenylephrine / pyrilamine
- phenylephrine / triprolidine
- Phenylgesic (acetaminophen / phenyltoloxamine)
- Phenylhistine (chlorpheniramine / phenylephrine)
- Phenylhistine DH (chlorpheniramine / codeine / pseudoephedrine)
- Phenylhistine DH Expectorant (chlorpheniramine / codeine / pseudoephedrine)
- Phenylhistine Expectorant (codeine / guaifenesin / pseudoephedrine)
- Phenytek (phenytoin)
- phenytoin
- Phenytoin Sodium (phenytoin)
- Phenytoin Sodium, Extended Release (phenytoin)
- Phenytoin Sodium, Prompt (phenytoin)
- Phlemex (dextromethorphan / guaifenesin)
- Phlemex Forte (dextromethorphan / guaifenesin / phenylephrine)
- Phlemex-PE (dextromethorphan / guaifenesin / phenylephrine)
- Phlemgesic (acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine)
- Phrenilin (acetaminophen / butalbital)
- Phrenilin Forte (acetaminophen / butalbital / caffeine)
- Phrenilin Forte (old formulation) (acetaminophen / butalbital)
- Phrenilin with Caffeine and Codeine (acetaminophen / butalbital / caffeine / codeine)
- pimozide
- Placidyl (ethchlorvynol)
- PMB (conjugated estrogens / meprobamate)
- PMS Formula Multi-Symptom (acetaminophen / pamabrom / pyrilamine)
- PMS Relief (acetaminophen / pamabrom / pyrilamine)
- Pneumotussin (guaifenesin / hydrocodone)
- Pneumotussin 2.5 (guaifenesin / hydrocodone)
- Pneumotussin HC (guaifenesin / hydrocodone)
- Polaramine (dexchlorpheniramine)
- Polaramine Expectorant (dexchlorpheniramine / guaifenesin / pseudoephedrine)
- Polaramine Repetabs (dexchlorpheniramine)
- Polmon (dexchlorpheniramine)
- Poly CS (brompheniramine / codeine / phenylpropanolamine)
- Poly DM (brompheniramine / dextromethorphan / phenylpropanolamine)
- Poly Hist CB (carbetapentane / guaifenesin)
- Poly Hist DHC (dihydrocodeine / phenylephrine / pyrilamine)
- Poly Hist DM (dextromethorphan / phenylephrine / thonzylamine)
- Poly Hist Forte (doxylamine / phenylephrine)
- Poly Hist Forte (old formulation) (phenylephrine / pyrilamine)
- Poly Hist HC (hydrocodone / phenylephrine / pyrilamine)
- Poly Hist PD (chlophedianol / thonzylamine)
- Poly Hist PD (old formulation) (chlorpheniramine / phenylephrine / pyrilamine)
- Poly Histine DM (brompheniramine / dextromethorphan / phenylpropanolamine)
- Poly Tan (dexbrompheniramine / pyrilamine)
- Poly Tan D (dexbrompheniramine / phenylephrine / pyrilamine)
- Poly Tan DM (dexbrompheniramine / dextromethorphan / phenylephrine / pyrilamine)
- Poly Tussin EX (dihydrocodeine / guaifenesin / phenylephrine)
- Poly-D (pheniramine / phenylpropanolamine / phenyltoloxamine / pyrilamine)
- Poly-Histine (pheniramine / phenyltoloxamine / pyrilamine)
- Poly-Histine CS (brompheniramine / codeine / phenylpropanolamine)
- Poly-Histine-D (pheniramine / phenylpropanolamine / phenyltoloxamine / pyrilamine)
- Poly-Tussin (chlorcyclizine / codeine)
- Poly-Tussin AC (brompheniramine / codeine / phenylephrine)
- Poly-Tussin D (chlorcyclizine / codeine / pseudoephedrine)
- Poly-Tussin DHC (brompheniramine / dihydrocodeine / phenylephrine)
- Poly-Tussin DM (chlorpheniramine / dextromethorphan / phenylephrine)
- Poly-Tussin EX Syrup (dihydrocodeine / guaifenesin / phenylephrine)
- Poly-Tussin HD (chlorpheniramine / hydrocodone / phenylephrine)
- Poly-Tussin XP (guaifenesin / hydrocodone / pseudoephedrine)
- Poly-Vent DM (dextromethorphan / guaifenesin / pseudoephedrine)
- Polyhist NC (codeine / pseudoephedrine / triprolidine)
- Polytine CS (brompheniramine / codeine / phenylpropanolamine)
- Polytine D (pheniramine / phenylpropanolamine / phenyltoloxamine / pyrilamine)
- Polytine DM (brompheniramine / dextromethorphan / phenylpropanolamine)
- Polytussin DM (dexchlorpheniramine / dextromethorphan / phenylephrine)
- Pondimin (fenfluramine)
- Potiga (ezogabine)
- Poxi (chlordiazepoxide)
- PP-Cap (propoxyphene)
- pramipexole
- Precedex (dexmedetomidine)
- pregabalin
- Prehist D (chlorpheniramine / methscopolamine / phenylephrine)
- Premsyn PMS (acetaminophen / pamabrom / pyrilamine)
- Pres Gen (dextromethorphan / guaifenesin / phenylephrine)
- Pres Gen Pediatric (dextromethorphan / guaifenesin / phenylephrine)
- Presgen B (brompheniramine / dextromethorphan / phenylephrine)
- Prialt (ziconotide)
- Primatuss 4 (chlorpheniramine / dextromethorphan)
- primidone
- Primlev (acetaminophen / oxycodone)
- Pristiq (desvenlafaxine)
- Pro-Chlo (chlophedianol / phenylephrine / pyrilamine)
- Pro-Clear (codeine / guaifenesin)
- Pro-Clear AC (codeine / pyrilamine)
- Pro-Med (promethazine)
- Pro-Red AC (codeine / dexchlorpheniramine / phenylephrine)
- Pro-Red AC (old formulation) (codeine / phenylephrine / pyrilamine)
- Probuphine (buprenorphine)
- prochlorperazine
- Procof (hydrocodone / potassium guaiacolsulfonate)
- Procof D (hydrocodone / potassium guaiacolsulfonate / pseudoephedrine)
- Procot (prochlorperazine)
- procyclidine
- Profen Forte DM (dextromethorphan / guaifenesin / pseudoephedrine)
- Profen II DM (dextromethorphan / guaifenesin / pseudoephedrine)
- Profen II DM Liquid (dextromethorphan / guaifenesin / pseudoephedrine)
- ProHist (dexchlorpheniramine / dextromethorphan / phenylephrine / pyrilamine)
- Prohist CD (chlophedianol / phenylephrine / triprolidine)
- Prohist CF (chlophedianol / triprolidine)
- ProHist DM (brompheniramine / dextromethorphan / pseudoephedrine)
- Prohist LQ (phenylephrine / triprolidine)
- Prohistine DM (brompheniramine / dextromethorphan / phenylpropanolamine)
- Prohistine-D (pheniramine / phenylpropanolamine / phenyltoloxamine / pyrilamine)
- Prolate (acetaminophen / oxycodone)
- Proleukin (aldesleukin)
- Prolex DH (hydrocodone / potassium guaiacolsulfonate)
- Prolex DM (dextromethorphan / potassium guaiacolsulfonate)
- Prolixin (fluphenazine)
- Prolixin Decanoate (fluphenazine)
- Prolixin Enanthate (fluphenazine)
- Promacet (acetaminophen / butalbital)
- promazine
- promethazine
- Promethazine DM (dextromethorphan / promethazine)
- Promethazine VC (phenylephrine / promethazine)
- Promethazine VC Plain (phenylephrine / promethazine)
- Promethazine VC with Codeine (codeine / phenylephrine / promethazine)
- Promethazine with Dextromethorphan (dextromethorphan / promethazine)
- Promethazine with DM (dextromethorphan / promethazine)
- Promethegan (promethazine)
- Prominol (acetaminophen / butalbital)
- Prop-A-Hist (chlorpheniramine / phenylephrine / phenylpropanolamine / phenyltoloxamine)
- Prop-A-Tane (brompheniramine)
- Propacet 100 (acetaminophen / propoxyphene)
- Propatuss Expectorant (guaifenesin / hydrocodone)
- propiomazine
- propoxyphene
- Propoxyphene Compound 65 (aspirin / caffeine / propoxyphene)
- Prosom (estazolam)
- Protid (acetaminophen / chlorpheniramine / phenylephrine)
- protriptyline
- Protuss (hydrocodone / potassium guaiacolsulfonate)
- Protuss DM (dextromethorphan / guaifenesin / pseudoephedrine)
- Protuss Tablet (atropine / chlorpheniramine / hyoscyamine / phenylephrine / phenylpropanolamine / scopolamine)
- Protuss-D (hydrocodone / potassium guaiacolsulfonate / pseudoephedrine)
- Prozac (fluoxetine)
- Prozac Weekly (fluoxetine)
- Prudoxin (doxepin topical)
- Pryil DM (dextromethorphan / phenylephrine / pyrilamine)
- PSE Allergy (carbinoxamine / pseudoephedrine)
- PSE Allergy DM (carbinoxamine / dextromethorphan / pseudoephedrine)
- PSE Brom DM (brompheniramine / dextromethorphan / pseudoephedrine)
- PSE Carb DM Drops (carbinoxamine / dextromethorphan / pseudoephedrine)
- PSE Carbinoxamine DM (carbinoxamine / dextromethorphan / pseudoephedrine)
- Pseubrom (brompheniramine / pseudoephedrine)
- Pseubrom-PD (brompheniramine / pseudoephedrine)
- Pseudacarb (carbetapentane / pseudoephedrine)
- Pseudatex HC (guaifenesin / hydrocodone / pseudoephedrine)
- Pseudo Carb (carbinoxamine / pseudoephedrine)
- Pseudo Carb DM (carbinoxamine / dextromethorphan / pseudoephedrine)
- Pseudo CM TR (chlorpheniramine / methscopolamine / pseudoephedrine)
- Pseudo Cough (dextromethorphan / guaifenesin / pseudoephedrine)
- Pseudo DM GG (dextromethorphan / guaifenesin / pseudoephedrine)
- Pseudo Max DMX (dextromethorphan / guaifenesin / pseudoephedrine)
- Pseudochlor (chlorpheniramine / pseudoephedrine)
- Pseudocot-C (chlorpheniramine / pseudoephedrine)
- Pseudocot-T (pseudoephedrine / triprolidine)
- Pseudodine C (codeine / pseudoephedrine / triprolidine)
- Pseudoephedrine Plus (chlorpheniramine / pseudoephedrine)
- pseudoephedrine / pyrilamine
- pseudoephedrine / triprolidine
- Pseudogest-DM (dextromethorphan / guaifenesin / pseudoephedrine)
- Pseudox M (carbinoxamine / methscopolamine / pseudoephedrine)
- Pulmari (brompheniramine / carbetapentane / phenylephrine)
- Pulmari-GP (carbetapentane / guaifenesin)
- PX Allergy Sinus PE (acetaminophen / chlorpheniramine / phenylephrine)
- Pyrelle HB (butabarbital / hyoscyamine / phenazopyridine)
- Pyrichlor PE (chlorpheniramine / phenylephrine / pyrilamine)
- Pyridium Plus (butabarbital / hyoscyamine / phenazopyridine)
- Pyril D (phenylephrine / pyrilamine)
- Pyril Mal Phenyl HCl (phenylephrine / pyrilamine)
- Pyril Tann-12 (phenylephrine / pyrilamine)
- pyrilamine
- Pyrlex (pyrilamine)
- Pyrlex CB (carbetapentane / pyrilamine)
- Pyrlex PD (phenylephrine / pyrilamine)
- Pyrroxate (acetaminophen / chlorpheniramine / phenylephrine)
More about difelikefalin
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- Dosage information
- During pregnancy
- Drug class: peripheral opioid receptor agonists
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.