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Ticar Dosage

Generic name: ticarcillin disodium
Dosage form: Injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Clinical experience indicates that in serious urinary tract and systemic infections, intravenous therapy in the higher doses should be used. Intramuscular injections should not exceed 2 grams per injection.

Adults

Bacterial septicemia

200 to 300 mg/kg/day by I.V. infusion in divided doses every 4 or 6 hours.

Respiratory tract infections

Skin and soft-tissue infections

Intra-abdominal infections

(The usual dose is 3 grams given every 4 hours [18 grams/day] or 4 grams given every 6 hours [16 grams/day] depending on weight and the severity of the infection.)

Infections of the female pelvis and genital tract

Urinary tract infections

Complicated:

150 to 200 mg/kg/day by I.V. infusion in divided doses every 4 or 6 hours. (Usual recommended dosage for average [70 kg] adults: 3 grams q.i.d.)

Uncomplicated:

1 gram I.M. or direct I.V. every 6 hours.

Infections complicated by renal insufficiency*:

Initial loading dose of 3 grams I.V. followed by I.V. doses, based on creatinine clearance and type of dialysis, as indicated below:

Creatinine clearance mL/min.:

over 60

3 grams every 4 hours

30 to 60

2 grams every 4 hours

10 to 30

2 grams every 8 hours

Less than 10

2 grams every 12 hours (or 1 gram I.M. every 6 hours)

less than 10 with hepatic dysfunction

2 grams every 24 hours (or 1 gram I.M. every 12 hours)

patients on peritoneal dialysis

3 grams every 12 hours

patients on hemodialysis

2 grams every 12 hours supplemented with 3 grams after each dialysis

*The half-life of ticarcillin in patients with renal failure is approximately 13 hours.

Children under 40 kg (88 lbs)

The daily dose for children should not exceed the adult dosage.

Bacterial septicemia

Respiratory tract infections

Skin and soft-tissue infections

Intra-abdominal infections

200 to 300 mg/kg/day by I.V. infusion in divided doses every 4 or 6 hours.

Infections of the female pelvis and genital tract

Urinary tract infections

Complicated:

150 to 200 mg/kg/day by I.V. infusion in divided doses every 4 or 6 hours.

Uncomplicated:

50 to 100 mg/kg/day I.M. or direct I.V. in divided doses every 6 or 8 hours.

Infections complicated by renal insufficiency:

Clinical data are insufficient to recommend an optimum dose.

Children weighing more than 40 kg (88 lbs) should receive adult dosages.

Neonates: In the neonate, for severe infections (sepsis) due to susceptible strains of Pseudomonas, Proteus and E. coli, the following ticarcillin dosages may be given I.M. or by 10 to 20 minute I.V. infusion:

Infants under 2000 grams body weight:

Infants over 2000 grams body weight:

Aged 0 to 7 days

75 mg/kg/12 hours

(150 mg/kg/day)

Aged 0 to 7 days

75 mg/kg/8 hours

(225 mg/kg/day)

Aged over 7 days

75 mg/kg/8 hours

(225 mg/kg/day)

Aged over 7 days

100 mg/kg/8 hours

(300 mg/kg/day)

This dosage schedule is intended to produce peak serum concentrations of 125 to 150 mcg/mL 1 hour after a dose of ticarcillin and trough concentrations of 25 to 50 mcg/mL immediately before the next dose.

NOTE: Gentamicin, tobramycin or amikacin may be used concurrently with ticarcillin for initial therapy until results of culture and susceptibility studies are known.

Seriously ill patients should receive the higher doses. Ticar has proved to be useful in infections in which protective mechanisms are impaired, such as in acute leukemia and during therapy with immunosuppressive or oncolytic drugs.

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