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Pronestyl-SR Dosage

Generic name: procainamide hydrochloride
Dosage form: Extended-Release Tablets

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The oral dose and interval of administration should be adjusted for the individual patient, based on clinical assessment of the degree of underlying myocardial disease, the patient’s age, and renal function.

As a general guide, for younger adult patients with normal renal function, an initial total daily oral dose of up to 50 mg/kg of body weight of PRONESTYL-SR Tablets (Procainamide Hydrochloride Extended-Release Tablets) may be used, given in divided doses, every six hours to maintain therapeutic blood levels.

*Initial dosage schedule guide only, to be adjusted for each patient individually, based on age, cardiorenal function, blood level (if available), and clinical response.
To provide approximately 50 mg per kg of body weight per day:*
Patients weighing
       lb kg
  88-100 40-50 500 mg q6h
132-154 60-70 750 mg q6h
176-198 80-90 1 g q6h      
    >220 >100 1.25 g q6h  

For older patients, especially those over 50 years of age, or for patients with renal, hepatic, or cardiac insufficiency, lesser amounts or longer intervals may produce adequate blood levels, and decrease the probability of occurrence of dose-related adverse reactions.

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