Pravigard PAC Dosage
Generic name: buffered aspirin and pravastatin Sodium
Dosage form: tablets
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The recommended daily dose of PRAVIGARD PAC is 40 mg of PRAVACHOL with either 81 mg or 325 mg of buffered aspirin. If a daily dose of PRAVACHOL 40 mg does not achieve desired cholesterol levels, 80 mg once daily (with 81 mg or 325 mg of buffered aspirin) is recommended. Some people may require lower doses of PRAVACHOL, and PRAVIGARD PAC is also available with PRAVACHOL 20 mg (see Pravachol below). The daily dose can be taken any time of day, with or without food. Because of the aspirin component, the dose should be taken with a full glass of water, unless the patient is fluid restricted.
PRAVIGARD PAC should be avoided in patients with severe hepatic or renal insufficiency (PRECAUTIONS: Buffered Aspirin).
The recommended starting dose is 40 mg once daily. PRAVACHOL can be administered as a single dose at any time of the day, with or without food. The maximal effect of a given dose is seen within 4 weeks. If a daily dose of 40 mg does not achieve desired cholesterol levels, 80 mg once daily is recommended.
Lower doses are recommended in some patients. A starting dose of 10 mg daily is recommended in patients with a history of significant renal or hepatic dysfunction. In patients taking immunosuppressive drugs such as cyclosporine (see WARNINGS: Skeletal Muscle) concomitantly with pravastatin, therapy should begin with 10 mg of pravastatin once-a-day at bedtime and titration to higher doses should be done with caution. The dose of pravastatin generally should not exceed 20 mg/day in those patients receiving concurrent immunosuppressive therapy.
Each dose of aspirin should be taken with a full glass of water unless patient is fluid restricted.
Prevention of Recurrent MI or Treatment of Chronic Stable Angina Pectoris
81 or 325 mg once a day. Continue therapy indefinitely.
The maintenance dose following revascularization procedures (CABG, angioplasty, carotid endarterectomy) is 81-325 mg/day of aspirin. Higher doses (to 650 mg/day) have also been recommended post endarterectomy.
- CABG: 325 mg daily starting 6 hours post-procedure. Continue therapy for 1 year post-procedure.
- Carotid Endarterectomy: Doses of 81 mg once daily to 650 mg twice daily, started presurgery, are recommended. Continue therapy indefinitely.