Medically reviewed by Drugs.com. Last updated on Jan 4, 2021.
Generic name: metolazone
Dosage form: Tablets USP
Therapy should be individualized according to patient response.
For initial treatment of mild to moderate hypertension, the recommended dose is one MYKROX Tablet (½ mg) once daily, usually in the morning. If patients are inadequately controlled with one ½ mg tablet, the dose can be increased to two MYKROX Tablets (1 mg) once a day. An increase in hypokalemia may occur. Doses larger than 1 mg do not give increased effectiveness.
The same dose titration is necessary if MYKROX Tablets are to be substituted for other dosage forms of metolazone in the treatment of hypertension.
If blood pressure is not adequately controlled with two MYKROX Tablets alone, the dose should not be increased; rather, another antihypertensive agent with a different mechanism of action should be added to therapy with MYKROX Tablets.
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