DynaCirc CR Dosage

The dosage of DYNACIRC CR Controlled Release Tablets should be individualized. The recommended initial dose of DYNACIRC CR is 5 mg once-daily as monotherapy or in combination with a thiazide diuretic. An antihypertensive response usually occurs within 2 hours, with the peak antihypertensive response occurring 8 to 10 hours post-dose; blood pressure reduction is maintained for at least 24 hours following drug administration. If necessary, the dose may be adjusted in increments of 5 mg at 2 to 4 week intervals up to a maximum dose of 20 mg/day. Adverse experiences are increased in frequency above 10 mg/day.

DYNACIRC CR Controlled Release Tablets should be swallowed whole and should not be bitten or divided.

The bioavailability (increased AUC) of immediate-release DYNACIRC is increased in elderly patients (older than 65 years of age), patients with hepatic functional impairment, and patients with mild renal impairment. Ordinarily, a starting dose of DYNACIRC CR 5 mg once-daily should be used in these patients.