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AN-DTPA Dosage

Generic name: pentetate calcium trisodium
Dosage form: injection

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Shielding should be utilized when preparing Technetium Tc 99m Pentetate Injection.

The suggested dose range of Technetium Tc 99m Pentetate Injection for intravenous administration, after reconstitution with oxidant-free Sodium Pertechnetate Tc 99m Injection to be administered to the average adult patient (70 kg) is:

Kidney imaging and glomerular
filtration rate estimation                             111 - 185 megabecquerels
                                                                     (3-5 mCi)

Brain imaging or assessment of
renal perfusion                                           370 - 740 megabecquerels
                                                                     (10-20 mCi)

Safety and effectiveness have not been established for doses of the drug containing more than 25 mg of pentetate calcium trisodium and 0.275 mg stannous chloride complexed with 740 megbequerels (20 millicuries) of Technetium Tc 99m.

The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. The solution should not be used if cloudy, discolored, or found to contain particulate matter.

Radiation Dosimetry

The estimated absorbed radiation doses2 to an average ADULT patient (70 kg) from an intravenous injection of a maximum dose of 740 megabecquerels (20 millicuries) of Technetium Tc 99m Pentetate Injection are shown in Table 4.

Table 4. Estimated Absorbed Radiation Doses and Effective Dose Equivalent Technetium Tc 99m Pentetate
Target Organ mGy/740 MBq rads/20 mCi
Kidneys 4.3 0.4
Urinary Bladder Wall 53.3 5.4
Testes 2.8 0.3
Ovaries 4.1 0.4
Effective Dose Equivalent 5.9 mSv 0.6 rem

2 Doses calculated using the model in MIRD Dose Estimate Report No. 12 (Journal Nuclear Medicine 24:503-505, 1984)

Radiation Doses to Hospital Personnel

The typical total body exposure to a person administering a maximum dose of 740 megabecquerels (20 mCi) of Technetium Tc 99m to a patient is about 0.02 mR.3

3Barrall RC, Smith SI: Personnel radiation exposure and protection from 99m Tc radiations. In Biophysical Aspects of the Medical Use of Technetium 99m, Kereiakes JG, Corey KR, eds, American Association of Physicists in Medicine, Monograph No 1, 1976, p77

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