Adenoscan Dosage

The recommended Adenoscan dose is 0.14 mg/kg/min infused over six minutes (total dose of 0.84 mg/kg) (Table 1).

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Administer Adenoscan only as a continuous peripheral intravenous infusion

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Inject Thallium-201 at the midpoint of the Adenoscan infusion (i.e., after the first three minutes of Adenoscan)

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Thallium-201 is physically compatible with Adenoscan and may be injected directly into the Adenoscan infusion set

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Inject Thallium-201 as close to the venous access as possible to prevent an inadvertent increase in the dose of Adenoscan (the contents of the intravenous tubing) being administered

Visually inspect Adenoscan for particulate matter and discoloration prior to administration. Do not administer Adenoscan if it contains particulate matter or is discolored.

There are no data on the safety or efficacy of alternative Adenoscan infusion protocols. The safety and efficacy of Adenoscan administered by the intracoronary route have not been established.

The nomogram displayed in Table 1 was derived from the following general formula:

                                                     0.14 (mg/kg/min) x
                                                   total body weight (kg)          =       Infusion rate
                                                Adenoscan concentration                     (mL/min)
                                                           (3 mg/mL)