Kuvan (sapropterin) Disease Interactions
There are 2 disease interactions with Kuvan (sapropterin):
Sapropterin (Includes Kuvan) ↔ liver impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Patients with liver impairment have not been evaluated in clinical trials with sapropterin. Hepatic damage has been associated in patients with impaired phenylalanine metabolism. Caution and monitoring is advised in patients with liver impairment who are receiving treatment with sapropterin.
Sapropterin (Includes Kuvan) ↔ renal impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Patients with renal impairment have not been evaluated in sapropterin clinical trials. Monitor patients who have renal impairment carefully if receiving treatment with sapropterin.
Kuvan (sapropterin) drug interactions
There are 28 drug interactions with Kuvan (sapropterin)
Kuvan (sapropterin) alcohol/food interactions
There is 1 alcohol/food interaction with Kuvan (sapropterin)
More about Kuvan (sapropterin)
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- Drug class: miscellaneous metabolic agents
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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