Xarelto (rivaroxaban) Disease Interactions
There are 5 disease interactions with Xarelto (rivaroxaban):
Factor Xa inhibitors (Includes Xarelto) ↔ bleeding
Severe Potential Hazard, Moderate plausibility. Applies to: Bleeding
The use of factor Xa inhibitors is contraindicated in patients with active pathological bleeding. Its use increases the risk of bleeding and can cause serious or fatal bleeding. Caution is recommended when prescribing these agents to patients at increased risk of bleeding. When using these agents, the risk of thrombotic events should be weighed against the risk of bleeding.
Factor Xa inhibitors (Includes Xarelto) ↔ hepatic impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Liver Disease
In general, the manufacturer recommends avoiding the use of factor Xa inhibitors in patients with moderate and severe hepatic impairment or with any hepatic disease associated with coagulopathy as drug exposure and bleeding risk may be increased.
Factor Xa inhibitors (Includes Xarelto) ↔ renal disease
Severe Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Some factor Xa inhibitors such as rivaroxaban and fondaparinux should be avoided in patients with CrCl <30 mL/min. Observe closely and promptly evaluate any signs or symptoms of blood loss in patients with CrCl 30 to 50 mL/min. Treatment should be discontinued in patients who develop acute renal failure while on treatment with these drugs.
Factor Xa inhibitors (Includes Xarelto) ↔ valvular heart disease
Severe Potential Hazard, Moderate plausibility. Applies to: Prosthetic Heart Valves
The use of factor Xa inhibitors is not recommended in patients with prosthetic heart valves as no studies have been conducted for safety and efficacy.
Rivaroxaban (Includes Xarelto) ↔ unstable blood pressure
Severe Potential Hazard, Moderate plausibility. Applies to: Hypotension
Initiation of rivaroxaban is not recommended acutely as an alternative to unfractionated heparin in patients with pulmonary embolism who present with hemodynamic instability or who may receive thrombolysis or pulmonary embolectomy.
Xarelto (rivaroxaban) drug interactions
There are 393 drug interactions with Xarelto (rivaroxaban)
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- Drug class: factor Xa inhibitors
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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