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Mozobil (plerixafor) Disease Interactions

There are 3 disease interactions with Mozobil (plerixafor):


Plerixafor (Includes Mozobil) ↔ Leukocytosis

Moderate Potential Hazard, Moderate plausibility

Applies to: Leukocytosis

The use of plerixafor in combination with granulocyte-colony stimulating factor increases leukocytes as well as hematopoietic stem cells populations. Caution should be exercised when administering this agent to patients with peripheral blood neutrophil counts above 50,000/mcL. It is recommended to monitor white blood cell counts during therapy.


Plerixafor (Includes Mozobil) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

It is recommended to reduce the dose of plerixafor by one-third to 0.16 mg/kg in patients with moderate to severe renal impairment.


Plerixafor (Includes Mozobil) ↔ Thrombocytopenia

Moderate Potential Hazard, Moderate plausibility

Applies to: Thrombocytopenia

The use of plerixafor may cause thrombocytopenia. Care and close monitoring are recommended when using plerixafor in patients with thrombocytopenia. Monitor counts in all patients and then undergo apheresis.

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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