Urinary Analgesic (phenazopyridine) Disease Interactions
There are 3 disease interactions with Urinary Analgesic (phenazopyridine):
Phenazopyridine (Includes Urinary Analgesic) ↔ G-6-Pd Deficiency
Severe Potential Hazard, Moderate plausibility
Applies to: G-6-PD Deficiency
Patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may be at increased risk for phenazopyridine-induced methemoglobinemia and hemolytic anemia. These conditions have occurred rarely in other patients, except due to acute phenazopyridine overdose or impaired renal function. Therapy with phenazopyridine should be administered cautiously in patients with G-6-PD deficiency.
References
- "Product Information. Pyridium (phenazopyridine)." Warner Chilcott Laboratories, Rockaway, NJ.
Phenazopyridine (Includes Urinary Analgesic) ↔ Hepatitis
Severe Potential Hazard, Moderate plausibility
Applies to: Liver Disease
The use of phenazopyridine is contraindicated in patients with severe hepatitis. Rare cases of hepatotoxicity have been associated with phenazopyridine, usually at overdose levels. Hypersensitivity hepatitis has also been reported. Therapy with phenazopyridine should be administered cautiously in patients with impaired hepatic function.
References
- "Product Information. Pyridium (phenazopyridine)." Warner Chilcott Laboratories, Rockaway, NJ.
Phenazopyridine (Includes Urinary Analgesic) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
The use of phenazopyridine is contraindicated in patients with impaired renal function. Phenazopyridine is primarily eliminated unchanged by the kidney and may accumulate to toxic levels during prolonged administration in such patients. Reported cases of toxicity due to overdosage have resulted in acute renal failure and methemoglobinemia. Likewise, administration of phenazopyridine to patients with preexisting renal failure has led to methemoglobinemia and hemolytic anemia. Phenazopyridine toxicity may be associated with a yellowish tinge of the skin or sclera.
References
- "Product Information. Pyridium (phenazopyridine)." Warner Chilcott Laboratories, Rockaway, NJ.
Urinary Analgesic (phenazopyridine) drug Interactions
There are 26 drug interactions with Urinary Analgesic (phenazopyridine)
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
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