Skip to Content

Antiflex (orphenadrine) Disease Interactions

There is 1 disease interaction with Antiflex (orphenadrine):


Orphenadrine (Includes Antiflex) ↔ anticholinergic effects

Severe Potential Hazard, Moderate plausibility. Applies to: Gastrointestinal Obstruction, Glaucoma/Intraocular Hypertension, Myasthenia Gravis, Urinary Retention, Esophageal Obstruction

Orphenadrine has mild anticholinergic activity, to which elderly patients are particularly sensitive. The manufacturer considers the use of orphenadrine to be contraindicated in patients with glaucoma, pyloric or duodenal obstruction, achalasia, prostatic hypertrophy, bladder neck obstruction, or myasthenia gravis. Orphenadrine should be used cautiously in other conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention and gastrointestinal obstructive disorders.


  1. "Product Information. Norflex (orphenadrine)." 3M Pharmaceuticals, St. Paul, MN.

Antiflex (orphenadrine) drug interactions

There are 806 drug interactions with Antiflex (orphenadrine)

Antiflex (orphenadrine) alcohol/food interactions

There is 1 alcohol/food interaction with Antiflex (orphenadrine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.