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Pergonal (menotropins) Disease Interactions

There are 6 disease interactions with Pergonal (menotropins):

Major

Gonadotropins (Includes Pergonal) ↔ Thromboembolism

Severe Potential Hazard, Moderate plausibility

Applies to: History - Thrombotic/Thromboembolic Disorder, Thrombotic/Thromboembolic Disorder, Obesity

Thromboembolic events, including venous thrombophlebitis, pulmonary embolism, pulmonary infarction, cerebrovascular occlusion (stroke), and arterial occlusion resulting in loss of limb, have been reported during administration of gonadotropin therapy, both in association with and independent of the Ovarian Hyperstimulation Syndrome. Therapy with gonadotropins should be administered cautiously to patients with or predisposed to thromboembolism.

References

  1. "Product Information. Humegon (menotropins)." Organon, West Orange, NJ.
Major

Menotropins (Includes Pergonal) ↔ Uncontrolled Non- Gonadal Endocrinopathies

Severe Potential Hazard, High plausibility

Applies to: Adrenal Insufficiency, Hyperadrenocorticism, Adrenal Tumor, Hyperaldosteronism, Thyroid Disease, Panhypopituitarism

The use of menotropins is contraindicated in patients with uncontrolled non- gonadal endocrinopathies such as thyroid, adrenal or pituitary disorders.

References

  1. "Product Information. Humegon (menotropins)." Organon, West Orange, NJ.
Major

Menotropins (Includes Pergonal) ↔ Cns Tumors

Severe Potential Hazard, High plausibility

Applies to: Pituitary Tumor, Brain/Intracranial Tumor

The use of menotropins is contraindicated in patients with CNS lesions, such as pituitary gland or hypothalamus tumors. Menotropins possess LH and FSH activity.

References

  1. "Product Information. Humegon (menotropins)." Organon, West Orange, NJ.
Major

Menotropins (Includes Pergonal) ↔ Vaginal Bleeding And Reproductive Organ Tumors

Severe Potential Hazard, High plausibility

Applies to: Abnormal Uterine Bleeding, Endometrial Dysplasia, Neoplasia -- Estrogen Dependent

The use of menotropins is contraindicated in female patients with abnormal vaginal bleeding of undetermined origin. Patients should be evaluated to ensure neoplastic lesions are not present. The use of menotropins is contraindicated in the presence of sex hormone dependent tumors of the reproductive tract or accessory organs.

References

  1. "Product Information. Humegon (menotropins)." Organon, West Orange, NJ.
Moderate

Gonadotropins (Includes Pergonal) ↔ Pulmonary Conditions

Moderate Potential Hazard, Moderate plausibility

Applies to: Pulmonary Impairment

Serious pulmonary conditions such as atelectasis, acute respiratory syndrome, and exacerbation of asthma have been reported in women treated with gonadotropins. Caution and monitoring is advised if used in women with pulmonary conditions.

Moderate

Menotropins (Includes Pergonal) ↔ Renal/Hepatic

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction, Liver Disease

Safety, efficacy and pharmacokinetics of menotropins have not been established in women with renal or hepatic insufficiency. Caution is advised.

Pergonal (menotropins) drug Interactions

There are 2 drug interactions with Pergonal (menotropins)

Pergonal (menotropins) alcohol/food Interactions

There is 1 alcohol/food interaction with Pergonal (menotropins)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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