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Lariam (mefloquine) Disease Interactions

There are 2 disease interactions with Lariam (mefloquine):

Major

Mefloquine (Includes Lariam) ↔ Psychosis/Depression

Severe Potential Hazard, High plausibility

Applies to: Psychosis, Depression, Neurosis, History - Psychiatric Disorder

The use of mefloquine for malaria prophylaxis is contraindicated in patients with active depression, a recent history of depression, generalized anxiety disorder, psychosis, schizophrenia, or other major psychiatric disorders. Mefloquine may cause psychiatric symptoms in some patients, including agitation, anxiety, depression, mood changes, panic attacks, paranoia, confusion, hallucinations, aggression, and psychotic behavior. Occasionally, these symptoms have been reported to continue long after mefloquine has been withdrawn due to its long half-life. Rare cases of suicidal ideation and suicide have occurred during mefloquine use, although a causal relationship has not been established. Therapy with mefloquine should be administered cautiously in patients with a previous history of depression. Psychiatric symptoms that occur during prophylactic use such as acute anxiety, depression, restlessness, or confusion should be considered prodromal to a more serious event, and the drug must be discontinued and an alternative medication substituted.

References

  1. "Product Information. Lariam (mefloquine)." Roche Laboratories, Nutley, NJ.
Major

Mefloquine (Includes Lariam) ↔ Seizures

Severe Potential Hazard, High plausibility

Applies to: Seizures

The use of mefloquine for malaria prophylaxis is contraindicated in patients with a history of seizures. Mefloquine can increase the risk of convulsions in patients with epilepsy and may lower the plasma levels of some anticonvulsant medications. Therefore, it should only be prescribed for curative treatment of malaria in such patients and only if there are compelling medical reasons for its use.

References

  1. "Product Information. Lariam (mefloquine)." Roche Laboratories, Nutley, NJ.

Lariam (mefloquine) drug Interactions

There are 477 drug interactions with Lariam (mefloquine)

Lariam (mefloquine) alcohol/food Interactions

There is 1 alcohol/food interaction with Lariam (mefloquine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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