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Amitiza (lubiprostone) Disease Interactions

There are 4 disease interactions with Amitiza (lubiprostone):


Lubiprostone (Includes Amitiza) ↔ GI obstruction

Severe Potential Hazard, Moderate plausibility. Applies to: Gastrointestinal Obstruction

Lubiprostone is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.


Lubiprostone (Includes Amitiza) ↔ diarrhea

Moderate Potential Hazard, Moderate plausibility. Applies to: Diarrhea, Electrolyte Abnormalities

Lubiprostone should not be prescribed to patients that have severe diarrhea. Care should be exercised when prescribing this drug to patients at risk of diarrhea and patients should be instructed to inform their physician if severe diarrhea occurs.


Lubiprostone (Includes Amitiza) ↔ dyspnea

Moderate Potential Hazard, Moderate plausibility. Applies to: Pulmonary Impairment

The use of lubiprostone may cause dyspnea. Care should be taken when prescribing this drug to patients that experienced dyspnea or when restarting the drug in those patients experiencing drug induced dyspnea.


Lubiprostone (Includes Amitiza) ↔ hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease

No dosage adjustment is needed in patients with mild hepatic impairment. It is recommended to modify the dose in patients with moderate and severe hepatic impairment as these patients experienced markedly higher systemic drug exposure that can cause an increased incidence and severity of adverse events.

Amitiza (lubiprostone) drug interactions

There is 1 drug interaction with Amitiza (lubiprostone)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.