Corlanor (ivabradine) Disease Interactions
There are 5 disease interactions with Corlanor (ivabradine):
Ivabradine (Includes Corlanor) ↔ conduction disturbances
Severe Potential Hazard, Moderate plausibility. Applies to: Arrhythmias
The use of ivabradine is contraindicated in sick sinus syndrome, sinoatrial block, or 3rd degree AV block, unless a functioning demand pacemaker is present, in those patients that are pacemaker dependent (heart rate maintained exclusively by the pacemaker), and in patients with resting heart rate less than 60 bpm prior to treatment.
Ivabradine (Includes Corlanor) ↔ heart failure
Severe Potential Hazard, Moderate plausibility. Applies to: Congestive Heart Failure
The use of ivabradine is contraindicated in acute decompensated heart failure.
Ivabradine (Includes Corlanor) ↔ hepatic impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Ivabradine is contraindicated in patients with severe hepatic impairment as it has not been studied in this population and an increase in systemic exposure is anticipated. No dose adjustment is required in patients with mild or moderate hepatic impairment.
Ivabradine (Includes Corlanor) ↔ hypotension
Severe Potential Hazard, Moderate plausibility. Applies to: Hypotension
The use of ivabradine is contraindicated in those patients with blood pressure less than 90/50 mmHg.
Ivabradine (Includes Corlanor) ↔ renal impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
No dosage adjustment is required for patients with creatinine clearance 15 to 60 mL/min. Care should be exercised when using this agent in patients with creatinine clearance below 15 mL/min as no data are available.
Corlanor (ivabradine) drug interactions
There are 318 drug interactions with Corlanor (ivabradine)
Corlanor (ivabradine) alcohol/food interactions
There is 1 alcohol/food interaction with Corlanor (ivabradine)
More about Corlanor (ivabradine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 1 Review
- Drug class: miscellaneous cardiovascular agents
- FDA Approval History
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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