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NovoLog Mix 70 / 30 FlexPen (insulin aspart / insulin aspart protamine) Disease Interactions

There are 3 disease interactions with NovoLog Mix 70 / 30 FlexPen (insulin aspart / insulin aspart protamine):

Moderate

Insulin (Includes NovoLog Mix 70/30 FlexPen) ↔ Renal/Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease, Renal Dysfunction, Liver Disease, Renal Dysfunction

Insulin requirements may be diminished in patients with renal or hepatic impairment due to reduced insulin metabolism and, in the latter case, also to reduced capacity for gluconeogenesis. Lower initial dosages may be appropriate, with careful monitoring of plasma glucose levels and dosing adjustments.

References

  1. "Product Information. Novolog (insulin aspart)" Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
  2. "Product Information. Lantus (insulin glargine)" Aventis Pharmaceuticals, Swiftwater, PA.
  3. "Product Information. Humulin BR (insulin)." Lilly, Eli and Company, Indianapolis, IN.
Moderate

Insulin- Hypokalemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypokalemia, Hypokalemia

Hypokalemia may commonly occur during treatment with insulin. Use with caution in patients who may be particularly at risk of developing hypokalemia (e.g., patients using potassium-lowering medications, patients taking medications sensitive to serum potassium concentrations).

Moderate

Insulin/Oral Hypoglycemic Agents (Includes NovoLog Mix 70/30 FlexPen) ↔ Hypoglycemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Adrenal Insufficiency, Malnourished, Autonomic Neuropathy, Panhypopituitarism, Anorexia/Feeding Problems, Anorexia/Feeding Problems, Panhypopituitarism, Autonomic Neuropathy, Malnourished, Adrenal Insufficiency

Hypoglycemia may commonly occur during treatment with insulin and/or oral hypoglycemic agents. Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during the use of these drugs, including those who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents.

References

  1. "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
  2. "Product Information. Novolog (insulin aspart)" Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
  3. Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
  4. "Product Information. Glucotrol (glipizide)." Pfizer US Pharmaceuticals, New York, NY.
  5. "Product Information. Lantus (insulin glargine)" Aventis Pharmaceuticals, Swiftwater, PA.
  6. "Product Information. Humulin BR (insulin)." Lilly, Eli and Company, Indianapolis, IN.
  7. "Product Information. Prandin (repaglinide)." Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
  8. "Product Information. Diabeta (glyburide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  9. "Product Information. Dymelor (acetohexamide)" Lilly, Eli and Company, Indianapolis, IN.
  10. "Product Information. Amaryl (glimepiride)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  11. "Product Information. Tolinase (tolazamide)" Pharmacia and Upjohn, Kalamazoo, MI.
  12. "Product Information. Micronase (glyburide)." Pharmacia and Upjohn, Kalamazoo, MI.
  13. "Product Information. Starlix (nateglinide)" Novartis Pharmaceuticals, East Hanover, NJ.
  14. "Product Information. Diabinese (chlorpropamide)." Pfizer US Pharmaceuticals, New York, NY.
  15. "Multum Information Services, Inc. Expert Review Panel"
View all 15 references

NovoLog Mix 70 / 30 FlexPen (insulin aspart / insulin aspart protamine) drug Interactions

There are 866 drug interactions with NovoLog Mix 70 / 30 FlexPen (insulin aspart / insulin aspart protamine)

NovoLog Mix 70 / 30 FlexPen (insulin aspart / insulin aspart protamine) alcohol/food Interactions

There is 1 alcohol/food interaction with NovoLog Mix 70 / 30 FlexPen (insulin aspart / insulin aspart protamine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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