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Aldara (imiquimod topical) Disease Interactions

There are 2 disease interactions with Aldara (imiquimod topical):


Imiquimod topical (Includes Aldara) ↔ eczema

Moderate Potential Hazard, High plausibility. Applies to: Eczema

Imiquimod may exacerbate inflammatory conditions of the skin. Local reactions are commonly associated with the use of imiquimod and may extend beyond the application site onto the surrounding skin. These reactions include erythema, edema, vesicles, erosion/ulceration, weeping/exudate, flaking/scaling/dryness, and scabbing/crusting. Therapy with topical imiquimod should be avoided or used with caution in patients with eczematous conditions.


  1. "Product Information. Aldara (imiquimod topical)." 3M Pharmaceuticals, St. Paul, MN.

Imiquimod topical (Includes Aldara) ↔ sunburn

Moderate Potential Hazard, High plausibility. Applies to: Sunburn

The use of imiquimod may be associated with heightened sunburn susceptibility. Patients with sunburn should be cautioned not to use imiquimod until fully recovered. Exposure to sunlight, including sunlamps, should be avoided or minimized during treatment, and protective clothing (e.g., hat) is recommended when exposure is unavoidable.


  1. "Product Information. Aldara (imiquimod topical)." 3M Pharmaceuticals, St. Paul, MN.

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.