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Anuprep-HC (hydrocortisone topical) Disease Interactions

There are 5 disease interactions with Anuprep-HC (hydrocortisone topical):

Moderate

Topical Corticosteroids (Includes Anuprep-HC) ↔ Diabetes

Moderate Potential Hazard, Low plausibility

Applies to: Abnormal Glucose Tolerance, Diabetes Mellitus

Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. Therapy with topical corticosteroids rarely produces these effects but should be administered cautiously nonetheless in patients with diabetes mellitus, glucose intolerance, or a predisposition to hyperglycemia. Systemic absorption of topical corticosteroids may occur depending on the vehicle and concentration of the preparation, the size of the application area, the integrity of the skin, and the duration of administration. Use of occlusive dressings over the applied areas may also increase percutaneous absorption. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults.

References

  1. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Co, Inc, West Point, PA.
  2. "Product Information. Cyclocort (amcinonide topical)." Fujisawa, Deerfield, IL.
  3. "Product Information. Proctocream HC 2.5% (hydrocortisone topical)." Schwarz Pharma, Mequon, WI.
  4. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals, Titusville, NJ.
  5. "Product Information. Cloderm (clocortolone topical)" Hermal Pharmaceutical Labs Inc, Delmar, NY.
  6. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa, Deerfield, IL.
  7. "Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
  8. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc, Palo Alto, CA.
  9. "Product Information. Lidex (fluocinonide)." Syntex Laboratories Inc, Palo Alto, CA.
  10. "Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
  11. "Product Information. Temovate (clobetasol)." Glaxo Wellcome, Research Triangle Park, NC.
  12. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
  13. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc, Corona, CA.
  14. "Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.
  15. "Product Information. Halog (halcinonide)." Bristol-Myers Squibb, Princeton, NJ.
  16. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome, Research Triangle Pk, NC.
  17. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  18. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc, Fort Worth, TX.
  19. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories, Melville, NY.
  20. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  21. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.
  22. "Product Information. Elocon (mometasone topical)." Schering Corporation, Kenilworth, NJ.
  23. "Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
View all 23 references
Moderate

Topical Corticosteroids (Includes Anuprep-HC) ↔ Diaper Rash

Moderate Potential Hazard, High plausibility

Applies to: Diaper Rash

Topical corticosteroids, especially the potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol), are generally not recommended for use in the treatment of diaper rash. Topical corticosteroids may be systemically absorbed, depending on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Given equivalent doses, small children are usually at the greatest risk for systemic toxicity such as adrenal suppression, Cushing's syndrome and intracranial hypertension because of their larger skin surface to body mass ratios. If topical corticosteroids are necessary to treat diaper rash, medium- to low-potency agents should preferably be used, and parents should be advised not to put tight-fitting diapers or plastic pants over the rash, since occlusion of treated area may increase percutaneous drug absorption.

References

  1. "Product Information. Proctocream HC 2.5% (hydrocortisone topical)." Schwarz Pharma, Mequon, WI.
  2. Reymann F, Kehlet H "Hypothalamic-pituitary-adrenocortical function. Association with topical application of betamethasone dipropionate." Arch Dermatol 115 (1979): 362-3
  3. "Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
  4. "Product Information. Cloderm (clocortolone topical)" Hermal Pharmaceutical Labs Inc, Delmar, NY.
  5. "Product Information. Elocon (mometasone topical)." Schering Corporation, Kenilworth, NJ.
  6. Howland WC "Fluticasone propionate: topical or systemic effects?" Clin Exp Allergy 26 ( Suppl (1996): 18-22
  7. "Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
  8. Nathan AW, Rose GL "Fatal iatrogenic Cushing's syndrome." Lancet 1 (1979): 207
  9. "Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.
  10. "Product Information. Cyclocort (amcinonide topical)." Fujisawa, Deerfield, IL.
  11. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories, Melville, NY.
  12. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  13. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome, Research Triangle Pk, NC.
  14. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Co, Inc, West Point, PA.
  15. Ohman EM, Rogers S, Meenan FO, McKenna TJ "Adrenal suppression following low-dose topical clobetasol propionate [published erratum appears in J R Soc Med 1988 May;81(5):308]." J R Soc Med 80 (1987): 422-4
  16. "Product Information. Lidex (fluocinonide)." Syntex Laboratories Inc, Palo Alto, CA.
  17. Salde L, Lassus A "Systemic side-effects of three topical steroids in diseased skin." Curr Med Res Opin 8 (1983): 475-80
  18. Macdonald A "Topical corticosteroid preparations. Hazards and side-effects." Br J Clin Pract 25 (1971): 421-5
  19. "Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
  20. Walsh P, Aeling JL, Huff L, Weston WL "Hypothalamus-pituitary-adrenal axis suppression by superpotent topical steroids." J Am Acad Dermatol 29 (1993): 501-3
  21. "Product Information. Temovate (clobetasol)." Glaxo Wellcome, Research Triangle Park, NC.
  22. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc, Fort Worth, TX.
  23. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
  24. May P, Stein EJ, Ryter RJ, Hirsh FS, Michel B, Levy RP "Cushing syndrome from percutaneous absorption of triamcinolone cream." Arch Intern Med 136 (1976): 612-3
  25. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.
  26. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  27. Stoppoloni G, Prisco F, Santinelli R, Sicuranza G, Giordano C "Potential hazards of topical steroid therapy." Am J Dis Child 137 (1983): 1130-1
  28. Gomez EC, Kaminester L, Frost P "Topical halcinonide and betamethasone valerate effects on plasma cortisol: acute and subacute usage studies." Arch Dermatol 113 (1977): 1196-202
  29. Young CA, Williams IR, MacFarlane IA "Unrecognised Cushing's syndrome and adrenal suppression due to topical clobetasol propionate." Br J Clin Pract 45 (1991): 61-2
  30. Novak E, Francom SF, Schlagel CA "Adrenal suppression with high-potency corticosteroid ointment formulations in normal subjects." Clin Ther 6 (1983): 59-71
  31. "Product Information. Halog (halcinonide)." Bristol-Myers Squibb, Princeton, NJ.
  32. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc, Corona, CA.
  33. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals, Titusville, NJ.
  34. Patel L, Clayton PE, Addison GM, Price DA, David TJ "Adrenal function following topical steroid treatment in children with atopic dermatitis." Br J Dermatol 132 (1995): 950-5
  35. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc, Palo Alto, CA.
  36. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa, Deerfield, IL.
  37. Ruiz-Maldonado R, Zapata G, Lourdes T, Robles C "Cushing's syndrome after topical application of corticosteroids." Am J Dis Child 136 (1982): 274-5
View all 37 references
Moderate

Topical Corticosteroids (Includes Anuprep-HC) ↔ Hyperadrenocorticism

Moderate Potential Hazard, Low plausibility

Applies to: Hyperadrenocorticism

The use of topical corticosteroids may rarely precipitate or aggravate conditions of hyperadrenocorticism. Topical corticosteroids may be systemically absorbed, depending on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults. The development of symptoms such as menstrual irregularities, acneiform lesions, cataracts and cushingoid features during topical corticosteroid therapy may indicate excessive use.

References

  1. May P, Stein EJ, Ryter RJ, Hirsh FS, Michel B, Levy RP "Cushing syndrome from percutaneous absorption of triamcinolone cream." Arch Intern Med 136 (1976): 612-3
  2. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.
  3. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
  4. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  5. Ruiz-Maldonado R, Zapata G, Lourdes T, Robles C "Cushing's syndrome after topical application of corticosteroids." Am J Dis Child 136 (1982): 274-5
  6. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc, Fort Worth, TX.
  7. "Product Information. Cloderm (clocortolone topical)" Hermal Pharmaceutical Labs Inc, Delmar, NY.
  8. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc, Corona, CA.
  9. Howland WC "Fluticasone propionate: topical or systemic effects?" Clin Exp Allergy 26 ( Suppl (1996): 18-22
  10. "Product Information. Halog (halcinonide)." Bristol-Myers Squibb, Princeton, NJ.
  11. "Product Information. Elocon (mometasone topical)." Schering Corporation, Kenilworth, NJ.
  12. "Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
  13. "Product Information. Proctocream HC 2.5% (hydrocortisone topical)." Schwarz Pharma, Mequon, WI.
  14. Watson WA, Kalb RE, Siskin SB, Freer JP, Krochmal L "The safety of halobetasol 0.05% ointment in the treatment of psoriasis [published erratum appears in Pharmacotherapy 1991;11(3):preceding Table of Contents]." Pharmacotherapy 10 (1990): 107-11
  15. "Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
  16. "Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.
  17. "Product Information. Lidex (fluocinonide)." Syntex Laboratories Inc, Palo Alto, CA.
  18. "Product Information. Cyclocort (amcinonide topical)." Fujisawa, Deerfield, IL.
  19. Salde L, Lassus A "Systemic side-effects of three topical steroids in diseased skin." Curr Med Res Opin 8 (1983): 475-80
  20. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories, Melville, NY.
  21. "Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
  22. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome, Research Triangle Pk, NC.
  23. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Co, Inc, West Point, PA.
  24. Nathan AW, Rose GL "Fatal iatrogenic Cushing's syndrome." Lancet 1 (1979): 207
  25. Macdonald A "Topical corticosteroid preparations. Hazards and side-effects." Br J Clin Pract 25 (1971): 421-5
  26. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  27. Stoppoloni G, Prisco F, Santinelli R, Sicuranza G, Giordano C "Potential hazards of topical steroid therapy." Am J Dis Child 137 (1983): 1130-1
  28. "Product Information. Temovate (clobetasol)." Glaxo Wellcome, Research Triangle Park, NC.
  29. Young CA, Williams IR, MacFarlane IA "Unrecognised Cushing's syndrome and adrenal suppression due to topical clobetasol propionate." Br J Clin Pract 45 (1991): 61-2
  30. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc, Palo Alto, CA.
  31. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa, Deerfield, IL.
  32. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals, Titusville, NJ.
View all 32 references
Moderate

Topical Corticosteroids (Includes Anuprep-HC) ↔ Infections

Moderate Potential Hazard, Moderate plausibility

Applies to: Infection - Bacterial/Fungal/Protozoal/Viral, Tuberculosis -- Latent

Topical corticosteroids may be systemically absorbed, depending on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Clinically significant local as well as systemic immunosuppressant and anti-inflammatory effects may occur, which can cause or exacerbate an infection. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. Therapy with topical corticosteroids should be administered cautiously in patients with latent or active infections, particularly if a potent agent is used on a large area for prolonged periods or if occlusive dressings are used. Effective antimicrobial therapy or other appropriate treatment should be instituted to treat the infection. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults. Occlusive dressings should not be used in patients with skin infection.

References

  1. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  2. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
  3. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc, Corona, CA.
  4. "Product Information. Halog (halcinonide)." Bristol-Myers Squibb, Princeton, NJ.
  5. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc, Fort Worth, TX.
  6. Macdonald A "Topical corticosteroid preparations. Hazards and side-effects." Br J Clin Pract 25 (1971): 421-5
  7. "Product Information. Temovate (clobetasol)." Glaxo Wellcome, Research Triangle Park, NC.
  8. "Product Information. Elocon (mometasone topical)." Schering Corporation, Kenilworth, NJ.
  9. "Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.
  10. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.
  11. "Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
  12. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  13. "Product Information. Proctocream HC 2.5% (hydrocortisone topical)." Schwarz Pharma, Mequon, WI.
  14. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome, Research Triangle Pk, NC.
  15. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories, Melville, NY.
  16. "Product Information. Cyclocort (amcinonide topical)." Fujisawa, Deerfield, IL.
  17. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Co, Inc, West Point, PA.
  18. "Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
  19. "Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
  20. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc, Palo Alto, CA.
  21. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals, Titusville, NJ.
  22. "Product Information. Lidex (fluocinonide)." Syntex Laboratories Inc, Palo Alto, CA.
  23. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa, Deerfield, IL.
  24. "Product Information. Cloderm (clocortolone topical)" Hermal Pharmaceutical Labs Inc, Delmar, NY.
View all 24 references
Moderate

Topical Corticosteroids (Includes Anuprep-HC) ↔ Ocular Toxicities

Moderate Potential Hazard, Low plausibility

Applies to: Cataracts, Glaucoma/Intraocular Hypertension

Prolonged use of corticosteroids may cause posterior subcapsular cataracts and elevated intraocular pressure, the latter of which may lead to glaucoma and/or damage to the optic nerves. Therapy with topical corticosteroids rarely produces these effects but should be administered cautiously nonetheless in patients with a history of cataracts, glaucoma, or increased intraocular pressure, especially when potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) are used in the periorbital area. Topical corticosteroids may be systemically absorbed, depending on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios.

References

  1. "Product Information. Cyclocort (amcinonide topical)." Fujisawa, Deerfield, IL.
  2. "Product Information. Lidex (fluocinonide)." Syntex Laboratories Inc, Palo Alto, CA.
  3. "Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
  4. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Co, Inc, West Point, PA.
  5. Cubey RB "Glaucoma following the application of corticosteroid to the skin of the eyelids." Br J Dermatol 95 (1976): 207-8
  6. Eisenlohr JE "Glaucoma following the prolonged use of topical steroid medication to the eyelids." J Am Acad Dermatol 8 (1983): 878-81
  7. "Product Information. Temovate (clobetasol)." Glaxo Wellcome, Research Triangle Park, NC.
  8. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc, Fort Worth, TX.
  9. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals, Titusville, NJ.
  10. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.
  11. "Product Information. Halog (halcinonide)." Bristol-Myers Squibb, Princeton, NJ.
  12. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc, Corona, CA.
  13. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
  14. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc, Palo Alto, CA.
  15. "Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
  16. "Product Information. Cloderm (clocortolone topical)" Hermal Pharmaceutical Labs Inc, Delmar, NY.
  17. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa, Deerfield, IL.
  18. Kitazawa Y "Increased intraocular pressure induced by corticosteroids." Am J Ophthalmol 82 (1976): 492-5
  19. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  20. "Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
  21. "Product Information. Proctocream HC 2.5% (hydrocortisone topical)." Schwarz Pharma, Mequon, WI.
  22. "Product Information. Elocon (mometasone topical)." Schering Corporation, Kenilworth, NJ.
  23. "Product Information. Topicort (desoximetasone topical)." Hoechst Marioin-Roussel Inc, Kansas City, MO.
  24. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories, Melville, NY.
  25. Aggarwal RK, Potamitis T, Chong NH, Guarro M, Shah P, Kheterpal S "Extensive visual loss with topical facial steroids." Eye 7(Pt 5) (1993): 664-6
  26. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome, Research Triangle Pk, NC.
  27. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
View all 27 references

Anuprep-HC (hydrocortisone topical) drug Interactions

There are 70 drug interactions with Anuprep-HC (hydrocortisone topical)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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