ActHIB (haemophilus b conjugate (prp-t) vaccine) Disease Interactions
There are 2 disease interactions with ActHIB (haemophilus b conjugate (prp-t) vaccine):
Vaccines (Includes ActHIB) ↔ Im Injection
Severe Potential Hazard, Moderate plausibility
Applies to: Thrombocytopenia, Thrombocytopathy, Coagulation Defect
In patients with thrombocytopenia or coagulation disorders, intramuscular injections may produce bleeding and hematomas. Patients with a platelet count less than 50,000/mm3 are at an increased risk. Caution is advised if the vaccine (e.g., plague vaccine, hepatitis A and B vaccines, and aluminum-adsorbed DTaP, DTP, DT, or Td) must be administered intramuscularly. The risk of bleeding may be minimized by vaccination immediately after the administration of replacement factor, use of a 23-gauge (or smaller) needle, and immediate application of direct pressure to the vaccination site for at least 2 minutes.
- "Product Information. Cholera vaccine (cholera vaccine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- American Academy of Pediatrics. Committee on Infectious Diseases; Peter G, ed. "Red BooK: Report of the Committee on Infectious Diseases. 24th" Grove Village, IL: American Academy of Pediatrics (1997):
- "Product Information. Engerix-B (hepatitis B vaccine)." SmithKline Beecham, Philadelphia, PA.
- "Product Information. Havrix (hepatitis A vaccine)." SmithKline Beecham, Philadelphia, PA.
- "Product Information. Plague Vaccine (plague vaccine)." Greer Laboratories Inc, Lenoir, NC.
Vaccines (Live Attenuated/Toxoid) (Includes ActHIB) ↔ Immunocompromised
Moderate Potential Hazard, Moderate plausibility
Applies to: Immunodeficiency
The expected antibody responses may not be obtained when live attenuated vaccines and/or toxoids are administered to immunosuppressed persons, including those receiving immunosuppressive therapy. Caution and close monitoring is advised.
ActHIB (haemophilus b conjugate (prp-t) vaccine) drug Interactions
There are 193 drug interactions with ActHIB (haemophilus b conjugate (prp-t) vaccine)
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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