Emend for Injection (fosaprepitant) Disease Interactions
There are 2 disease interactions with Emend for Injection (fosaprepitant):
Fosaprepitant (Includes Emend for Injection) ↔ QT prolongation
Moderate Potential Hazard, Moderate plausibility. Applies to: Long QT Syndrome
Fosaprepitant, a prodrug of aprepitant, is a weak inhibitor of CYP3A4, and aprepitant is a substrate, inhibitor, and inducer of CYP3A4. An increased plasma concentration of fosaprepitant could cause QT prolongation. Caution is advised in patients with long QT, and in patients receiving other drugs that are CYP3A4 substrates as it may result in a risk of higher plasma concentrations and adverse events. Close monitoring is recommended in these patients.
Fosaprepitant (Includes Emend for Injection) ↔ severe hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
There are no clinical or pharmacokinetic data in patients with severe hepatic impairment (Child-Pugh greater than 9), therefore caution and monitoring is recommended when using fosaprepitant in these patients.
Emend for Injection (fosaprepitant) drug interactions
There are 539 drug interactions with Emend for Injection (fosaprepitant)
More about Emend for Injection (fosaprepitant)
- Emend for Injection Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: NK1 receptor antagonists
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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